Spatial transcriptomics (ST) maps gene expression within tissue architecture, surpassing scRNA-seq by preserving context. This review evaluates 77 platforms—from high-resolution imaging to whole-transcriptome sequencing—and 600 computational tools for analysis and multi-omics integration.

References:

• Zi-Zhen Guo, Renyan Wu, Weixiang Li, Keyu Yang, Xuexiang Ying, Hamid Alinejad-Rokny, Youqiong Ye. Mapping biology in space: from spatial transcriptomics platforms to analytical tools and databases. Science Bulletin. 2026.