Researchers developed a cell-type-specific lysosomal atlas of the brain using LysoIP and proteomics. They identified SLC45A1 as a critical lysosomal glucose transporter in neurons. Its absence impairs lysosomal acidity, V-ATPase assembly, and metabolic recycling, linked to disease.

References:

• Ghoochani A, Heiby J C, Rawat E S, et al. Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder[J]. Cell, 2026.