<h1>Researchers used a yeast-based SPS system to identify atazanavir as a pan-PAM for family A GPCRs. It acts as a molecular glue, stabilizing a non-canonical megacomplex through pendulum engagement of β-arrestin, leading to sustained G protein signaling from endosomes.</h1>References:<ul> <li>He G, Sun Q, Xu X, et al. A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator[J]. Cell, 2026.</li></ul>

Researchers used a yeast-based SPS system to identify atazanavir as a pan-PAM for family A GPCRs. It acts as a molecular glue, stabilizing a non-canonical megacomplex through pendulum engagement of β-arrestin, leading to sustained G protein signaling from endosomes.References: He G, Sun Q, Xu X, et al. A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator[J]. Cell, 2026.

Researchers used a yeast-based SPS system to identify atazanavir as a pan-PAM for family A GPCRs. It acts as a molecular glue, stabilizing a non-canonical megacomplex through pendulum engagement of β-arrestin, leading to sustained G protein signaling from endosomes.References:<ul> <li>He G, Sun Q, Xu X, et al. A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator[J]. Cell, 2026.</li></ul>

536-Atazanavir Mediates Sustained GPCR Signaling

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536-Atazanavir Mediates Sustained GPCR Signaling

536-Atazanavir Mediates Sustained GPCR Signaling