This study identifies a neuroimmune loop linking the heart and brain after myocardial infarction. The circuit involves sensory vagus neurons, the hypothalamic paraventricular nucleus, and the superior cervical ganglia. Interrupting this loop reduces inflammation and scarring.

References:

• Yadav S, Ninh V K, Lovelace J W, et al. A triple-node heart-brain neuroimmune loop underlying myocardial infarction[J]. Cell, 2026, 189(3): 800-817. e20.