A neuro-epithelial-immune axis regulates skin health. Sympathetic nerves communicate with keratinocytes via ADRB2 signaling to control CXCL16 levels. Inhibiting these nerves expands CD8+ T RM cells, boosting immunosurveillance against melanoma and other cancers.

References:

• Zhang P, Miao J, Yu H, et al. Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin[J]. Cell, 2026.