In this episode the guys chat about the use of creatine in conjunction with BFR resistance training. As usual they breakdown our current knowledge with an emphasis on safety and then get into the meat and potatoes of what has been shown in the BFR literature.

Here are the papers mentioned:

Rawson, E. S., Clarkson, P. M., & Tarnopolsky, M. A. (2017). Perspectives on Exertional Rhabdomyolysis. Sports Medicine , 47(Suppl 1), 33–49.

Harmon, K. K., Stout, J. R., Fukuda, D. H., Pabian, P. S., Rawson, E. S., & Stock, M. S. (2021). The Application of Creatine Supplementation in Medical Rehabilitation. Nutrients, 13(6). https://doi.org/10.3390/nu13061825

Olsen, S., Aagaard, P., Kadi, F., Verney, G. T., Olesen, J. L., Suetta, C., & and Kjær, M. (2006). Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training. The Journal of Physiology, 573, 525–534.

Hespel, P., Op’t Eijnde, B., Van Leemputte, M., Ursø, B., Greenhaff, P. L., Labarque, V., Dymarkowski, S., Van Hecke, P., & Richter, E. A. (2001). Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. The Journal of Physiology, 536(Pt 2), 625–633.

Hultman, E., Söderlund, K., Timmons, J. A., Cederblad, G., & Greenhaff, P. L. (1996). Muscle creatine loading in men. Journal of Applied Physiology, 81(1), 232–237.

Suga, T., Okita, K., Takada, S., Omokawa, M., Kadoguchi, T., Yokota, T., Hirabayashi, K., Takahashi, M., Morita, N., Horiuchi, M., Kinugawa, S., & Tsutsui, H. (2012). Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. European Journal of Applied Physiology, 112(11), 3915–3920.

Ingemann-Hansen, T., Halkja~r-Kristensen, J., & Halskov, O. (1981). Skeletal Muscle Phosphagen and Lactate Concentrations in lschaemic Dynamic Exercise. European Journal of Applied Physiology, 46, 261–270.

Sousa-Silva, R. C., Holewa, J. M., de Araújo Pessôa, K., Zhi Xia, Z., Lauver, J. D., Rossi, F. E., & Zanchi, N. E. (2/2023). Creatine supplementation combined with blood flow restriction training enhances muscle thickness and performance- a randomized, placebo-controlled, and double-blind study.pdf. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. https://doi.org/10.1139/apnm-2022-0209

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