The paper details the development of two-layer DNA seqFISH+, a high-resolution imaging technology designed to map the three-dimensional organization of the genome in single cells. By simultaneously analyzing over 100,000 genomic loci, the nascent transcriptome, and various subnuclear structures, researchers can observe how chromatin compartments vary across different cell types in complex tissues ...去小宇宙查看完整单集简介
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