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Colchicinum
Synonyms: English: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a] heptalen-7-yl) acetamide; French: Colchicine.
Description: Colchicinum is a major alkaloid of Colchicum autumnale L (Meadow saffron), the dried corm of which contains 0.3-0.5% of colchicine. The isolated compound is in the form of pale yellow, amorphous scales or powder. It is odorless, or nearly so, and darkens on exposure to light. It is extremely poisonous.
History and authority: Boericke: Materia Medica and Repertory.
Potencies: 3x and higher with Dispensing Alcohol.
Prescribed dose: Trituration form
Caution: Continued use to relieve rheumatic pain may lead to other side effects. Not to be used as daily dependance drug.
Intestinal catarrh with shreddy membranes;Convulsive jerkings of right hand;Rheumatic fever, gout, ends and pericarditis,Pleurisy, arthritis deformans in early stages, intense pain of rheumatismConnected Rubrics in Synthesis Repertory
CHEST – INFLAMMATION – Heart – Pericardium – rheumaticEXTREMITIES – CLENCHING – FingersEXTREMITIES – INFLAMMATION – Joints – chronicEXTREMITIES – JERKING – Hands – convulsive – right handEXTREMITIES – PAIN – Joints – goutyEXTREMITIES – PAIN – Joints – rheumaticEXTREMITIES – TWITCHING – Hands – convulsiveFEVER – FEVER, heat in generalGENERALS – COLLAPSEGENERALS – CONVULSIONSGENERALS – INFLAMMATION – Joints; of – deformans; arthritisGENERALS – WEAKNESSRECTUM – DIARRHEARECTUM – PAIN – stool – during – agg.RECTUM – PAIN – stool – during – agg. – tenesmusSLEEP – SLEEPINESSSLEEP – SLEEPLESSNESSSTOMACH – ERUCTATIONSURINE – CLOUDYInformation from DICTIONARY OF PRACTICAL MATERIA MEDICA, J. H. CLARKE
DiarrhoeaFeverIntestinal catarrhProstrationSleeplessnessSpasmsCharacteristics: This alkaloid has been proved and the symptoms are sufficiently distinctive, though I am not aware of any clinical experience with it. The symptoms point strongly to its use in that form of intestinal catarrh characterised by the appearance of shreddy membranes; and the symptom, “convulsive jerkings of right hand,” should prove a valuable indication, if not a keynote.
Relations: Compare: Ars., Caust., Colch.
ENCLYCLOPEDIA OF PURE MATERIA MEDICA, T F ALLEN
Schroff’s provings, Oest. Zeit. f. Pract. Heilk., 1856, 22-24, Heinrich took 01 of a gramme, and after a week took 02 gramme;
The only case of poisoning known, bear. Rudolph-Stift, 227, 1867, a woman, aged twenty, took a solution of 45 milligrammes (Husemann’s Pflanzenstoffe, 498).
Eye: Pupils widely dilated
Face: Tearing pains in the face
Mouth: Increased secretion of saliva
EructationEructations, nausea, and great desire to vomitNausea and vomitingSlight nausea, and an uncomfortable sensation, which distracted the attention of the prover from the lecture to which he was listeningOn rising from bed, at night, nausea suddenly increased, and was followed by vomiting of undigested food, and afterwards of a bitter greenish fluid; the vomiting was repeated early in the morningVomiting of greenish substances, frequently repeatedVomiting of blood for nine or ten daysPains in epigastric region (after four hours)Excessive sensitiveness of epigastric regionDistension and sensitiveness in the abdomenFrequent rumbling in the bowelsUrging to stool, causing him to leave his bed, followed by copious pasty evacuation, with excessive tenesmus; this was repeated three times within a short periodTwo stools on the second day, one on the third day, three on the fourth day, all accompanied by tenesmus, and consisting of a thin fluid with numerous flakes, looking like the cooked white or an egg, in pieces from two to four lines longStools thin, yellowish-green, and slimy, accompanied by pain (second day)Liquid stoolsUrinary organs: Urine turbid, depositing a copious white sediment
Very great exhaustion on the second day after taking Colchicin, increased to a feverish excitement, lasting for two days, so that he was obliged to keep his bed on the second daySlight somnolency and collapseAwakened from sleep soon after midnight by uneasy dreamsThe fever appeared as a chill about noon on the first day, followed by violent heat, lasting several hours, with increased thirst, very rapid pulse, confusion of the head, uneasiness, and sleeplessnessYour valuable feedback and reviews are welcome.
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