May 15, 2023

#74: fentanyl (Duragesic) | Used in Anesthesia, Post-Operative Pain

14 minutes

Fentanyl is an opiate agonist, anesthetic, narcotic most commonly used in pain management. Comes in a large variety of dosage forms but is most commonly seen as a transdermal patch. It produces analgesia and sedation by binding to the mu- or k- receptor and alters the perception of pain. It is well absorbed and used in the transdermal dosage form it best when used on a fatty part of the body due to its highly lipophilic nature. Common side effects are impaired coordination, nausea/vomiting, bradycardia, euphoria, and dizziness. There is a Black Box Warning for Addiction/Abuse/Misuse, Respiratory Depression, CYP450 3A4 interactions, and Risks from Benzodiazepine/CNS Depressant use.

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