In our conversation with Paul Turner we covered his research on phage evolution and how he has applied his findings to treating Cystic fibrosis patients against MDR Pseudomonas aeruginosa with phage therapy.

Phages have the power to select on certain bacterial treats, thus, the understanding of how bacteria develop resistance to phage can make us be better prepared to respond to this resistance. Paul Turner´s lab is applying this knowledge, predicting the trade-offs of bacterial resistance to phage, to achieve bacterial killing reversing the antibiotic resistance.

He talked about ongoing work in this matter, how these findings are translated from in vitro to in vivo, and he also gave really inspiring and insightful advice for the people in the field.

https://turnerlab.yale.edu/publications/personalized-inhaled-bacteriophage-therapy-decreases-multidrug-resistant-pseudomonas

Dr. Paul Turner is the Rachel Carson Professor of Ecology and Evolutionary Biology at Yale University, and Microbiology faculty member at Yale School of Medicine. his research focuses on the evolutionary genetics of viruses, particularly RNA viruses, and phages that infect bacterial pathogens & the use of phages to treat antibiotic-resistant bacterial diseases.

He is also quite active in science-communication and outreach to the general public, and he has a TED talk that you can find online on the use of phages to treat antibiotic resistant bacteria.