This research introduces LAMBADA, a comprehensive 3D anatomical atlas designed to map the postnatal development of the mouse brain with high temporal precision. By integrating light-sheet microscopy, MRI data, and spatial transcriptomics, the authors identified three distinct stages of cerebral vascularization: isometric expansion, regional specialization, and network refinement. Early growth is primarily driven by hypoxia-sensing pathways, whereas later stages align with neuronal maturation and the onset of sensory-driven activity. This resource reveals that vascular density is not a uniform process but rather a specialized transformation that coordinates with synaptic programs and glial stabilization. Ultimately, the study provides a multimodal framework for understanding how neurovascular interactions shape the functional architecture of the maturing mammalian brain.

References:

• de Launoit E, Skriabine S, Doumazane E, et al. The spatiotemporal dynamics of postnatal vascularization in the mouse brain[J]. Cell, 2026.