Recent neuroscientific research identifies a specialized developmental structure called the Arc within the subventricular zone of mammals with folded brains, such as humans, primates, and pigs. This complex region facilitates the continued migration of inhibitory interneurons after birth, a process notably absent in species with smooth brains like mice. Using transcriptomic sequencing and advanced imaging, scientists discovered that these young neurons travel along distinct dorsal and ventral pathways to reach the frontal and temporal cortices. This prolonged migration significantly contributes to the high density of VIP+ neurons in higher cognitive areas, potentially influencing brain plasticity. Because this process occurs during a critical developmental window, it may offer new insights into neurodevelopmental disorders like autism and epilepsy.

References:

• Kim J Y, Poddar A, Sandoval K, et al. An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains[J]. Nature Neuroscience, 2025, 28(8): 1598-1609.

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