This research investigates how aging affects cerebral white matter by examining the microvascular networks in mice. Using advanced deep multi-photon imaging, researchers discovered principal cortical venules (PCVs), which serve as the primary drainage system for deep brain tissues and the corpus callosum. The study found that aging causes capillary rarefaction and constriction specifically within these drainage branches, leading to hypoperfusion. This restricted blood flow is directly linked to demyelination and inflammatory responses like gliosis. By simulating similar conditions in younger mice, the authors confirmed that impaired vascular drainage is a key driver of age-related cognitive decline rather than just a byproduct. Thus, protecting these venous networks may provide a new therapeutic path for maintaining brain health during aging.

References:

• Stamenkovic S, Schmid F, Gurler G, et al. Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging[J]. Nature Neuroscience, 2025, 28(9): 1868-1882.