This study examines how the C9orf72 gene mutation affects the immune response in the central nervous system of patients with amyotrophic lateral sclerosis (ALS). By comparing genetic and sporadic forms of the disease, researchers discovered that the C9orf72 mutation causes haploinsufficiency, which prevents microglia from transitioning into necessary reactive and protective states. Unlike sporadic...去小宇宙查看完整单集简介
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