This research outlines a complex, brain-wide network called the allostatic–interoceptive system, which is responsible for regulating the body's metabolic resources and interpreting internal signals. By utilizing 7 Tesla fMRI technology, the study provides unprecedented detail regarding the connections between the cerebral cortex and small, deep structures within the brainstem and midbrain. The findings demonstrate that this system involves an integration of the default mode and salience networks, mirroring anatomical pathways previously identified in animal research. Notably, the study highlights that many of these regions act as "rich club" hubs, serving as a high-capacity backbone for global communication across the brain. Ultimately, the results suggest that allostasis and interoception are fundamental processes that shape a wide range of psychological experiences, including emotion, cognition, and perception.

References:

• Zhang J, Chen D, Deming P, et al. Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI[J]. Nature Neuroscience, 2025: 1-12.

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