Research identifies a novel skin-hypothalamus axis that explains how repeated heat stress causes long-term metabolic dysfunction. The study reveals that heat exposure triggers the release of the protein KLK14 from the skin, which travels through the blood to the brain and induces lasting epigenetic changes in hypothalamic LRRC7⁺ astrocytes. These reprogrammed astrocytes suppress specific neurons i...去小宇宙查看完整单集简介
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