This research identifies Lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as the primary molecular tethers responsible for anchoring heterochromatin to the nuclear periphery in mammalian cells. By systematically depleting various nuclear envelope proteins, the authors discovered that losing these specific anchors causes dense genetic material to detach from the edge and relocate i...去小宇宙查看完整单集简介
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