Dov is once again joined by Dr. Brian Cornblatt, Chief Medical Officer at BioHarvest Sciences, for a spirited and in-depth conversation. They take a deep dive into the detox process and discuss the science behind VINIA, a revolutionary supplement that leverages the power of technology to deliver unparalleled bioavailability of detoxifying phytochemical compounds. Dr. Cornblatt is a Johns Hopkins University School of Medicine Graduate with a Ph.D. in Pharmacology and Molecular Sciences and a postdoctoral fellowship from the Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences Division of Toxicology. He is also the inventor of 7 issued patents and 9 pending provisional patents focused on plant-based bioactive compounds and health promotion. 

RESOURCES

The Science of VINIA

VINIA’s Solubility Advantage

VINIA’s Bioavailability Advantage      

Research Article

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SHOW NOTES

• 5:15 – Dr. Cornblatt explains why he likes discussing the chemical compounds heterocyclic amines and benzene
• 9:05 – Testing for benzene levels in the body
• 10:30 – Objective methods Dr. Cornblatt implements to determine one’s ability to detox benzene using phytochemicals; Lab report measuring benzene levels (see page 4).
• 11:34 – Phase 2 enzymes and how they work like a dimmer switch; how plant-based bioactive compounds can modulate the switch 
• 17:27 – Glutathione S Transferase: how these enzymes work and the many redundancies at the cellular level
• 19:30 – How Glutathione is made and how plant phytochemicals can upregulate it
• 21:40 – Are plant phytonutrients antioxidants, pro-oxidants or “indirect” antioxidants? 
• 24:14 – The evolutionary principle behind how and why these plant compounds produce phytochemicals 
• 26:32 – Benefits of taking phytochemicals; stimulation of NRF2, ET1 (impacts vasoconstriction) and eNOS (impacts vasodilation); how VINIA stimulates all 3 pathways, helping to modulate blood pressure and oxygenate the blood, aiding in the reversal of chronic fatigue
• 31:40 – How the piceid form of resveratrol in VINIA is vastly different from standard resveratrol (cis and trans form); unparalleled absorbability and bioavailability and the innovative ways Dr. Cornblatt’s team achieves this
• 41:00 – New innovations coming soon from BioHarvest 
• 44:00 – VINIA’s impact on insulin sensitivity; VINIA's wide-ranging polyphenolic content versus standard resveratrol's limited polyphenolic content
• 48:55 – LDL cholesterol vs oxidized LDL and how VINIA upregulates a phase 2 enzyme called PON1, preventing oxidation of LDL cholesterol
• 59:37 – The value of genetic testing when applying nutraceuticals and pharmaceuticals in a customized way 
• 1:04 – Does the body recognize the difference between human-made chemicals and plant-derived phytochemicals? Can we over-stimulate NRF2 with phytochemicals if it’s chronically stimulated by ubiquitous human-made chemicals?
• 1:11 – Is there merit to taking multiple supplemental phytochemicals if any 1 phytochemical in isolation has been shown to upregulate NRF2?