While the Columbian Exchange is mostly related to the trading of food, animals, and culture between Europe and the Americas, there is also one other thing that was exchanged too - disease. After the colonization of the New World, diseases such as smallpox, carried by European colonizers, ravaged the Indigenous populations of the Americas. In this episode, we will explore the background of colonization, what smallpox is, and examine the tragedy of the Siege of Fort Pitt.