The Cracking Cancer Podcast

A Lab for Curative Intent Treatments with Dr. Concannon. Episode 38.


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In this revealing episode of "Cracking Cancer," host Dr. Kyle Concannon pulls back the curtain on his role as a physician-scientist at the University of Colorado. Joined by patient advocate Samantha Murrell, Dr. Kyle demystifies the "black box" of oncology research, discussing the intense process of setting up a new laboratory and the personal pivot that reshaped his career.

 

Dr. Kyle shares the logistical and emotional challenges of running an independent lab—from the high cost of reagents and the competitive nature of grant funding to the personal urgency that arose when his own boss was diagnosed with lung cancer. The conversation dives deep into the specific preclinical models used to fight disease, including cell lines and mouse models, explaining how they serve as the first line of defense before human trials. Dr. Kyle also highlights his lab's most exciting work: developing enhanced CAR T-cell therapies designed to not just manage, but potentially cure metastatic cancer. This episode is a raw look at the grit required to move science forward and the powerful partnership between researchers and the patients who drive their mission.

 

Key Takeaways:

  1. The Reality of Setting Up a Lab
  2. Cell Lines vs. Mouse Models
  3. The High Cost of "Reagents"
  4. Pivoting for Impact
  5. The Promise of Next-Gen CAR T-Cell Therapy
  6.  

    Want to get more involved with cancer research and support the podcast, visit the link below: ⬇️

    https://www.crackingcancer.org/get-involved

     

    Chapters:

    (00:00) Dr. Kyle's Secret Lab Revealed
    (05:59) Understanding Reagents and Research Costs
    (14:35) Building the Right Team
    (27:17) Mouse Models in Cancer Research
    (34:17) Challenges in Preclinical Research
    (45:41) Funding and Collaborations
    (56:48) The Future of Cancer Research
    (01:05:46) Concluding Thoughts and Call to Action
     

    The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org

     

    Attributions

    The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

     

    X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X

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    The Cracking Cancer PodcastBy Dr. Concannon and the Patient Community