Megan O'Hare talks to Ivanna Pavisic and Antoinette O’Connor about their different projects relating to ‘Longitudinal research study of familial Alzheimer’s disease' and the changes that occur at this clinically silent stage.

Ivanna and Antoinette both work at the University College London, Dementia Research Centre which has had a longstanding research programme in autosomal dominantly inherited familial Alzheimer’s disease (FAD) led by Professor Nick Fox.

In this podcast they talk about how the study provides a unique opportunity to explore the presymptomatic period of AD as pathogenic mutations are effectively 100% penetrant and the age at onset is relatively consistent within families and they also talk about the use and need for reliable biomarkers and cognitive tests.

You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk

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