10,000 – that’s the magic number of steps often recommended for a healthy lifestyle. With recent research looking into whether that number is an accurate benchmark for health, could the number of steps taken per day have an impact on brain health and, specifically, cognitive decline? That’s precisely what a new study from Harvard Medical School and Mass General Brigham sought to examine, looking at how physical activity, specifically step count, impacted cognitive decline for those living with Alzheimer’s disease. Dr. Bri Breidenbach and Sarah Lose join the podcast to break down the results of this new study, as well as share what current research says about the effect of other kinds of physical activity, such as different intensity exercises, on the brain and Alzheimer’s progression.

Guests: Bri Breidenbach, PhD, scientist, exercise physiologist, Okonkwo Lab, and Sarah Lose, MS, research program manager, exercise physiologist, Okonkwo Lab, UW School of Medicine and Public Health

Read the study, “Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease,” published by the journal Nature Medicine on their website.

Learn more about Dr. Breidenbach and Sarah Lose’s work on the Okonkwo Lab website.

Read “Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK,” mentioned by Dr. Breidenbach at 12:01, on JAMA Neurology’s website.

Listen to Sarah Lose’s previous episode, “Building the Brain: Finding the Cognitive Benefits of Physical Activity,” on our website.

Learn more about physical activity and the six pillars of brain health on our website.

Complete the Dementia Matters Feedback Survey to let us know what our show is doing well and how we can improve in the New Year! This anonymous survey is estimated to take about 5 minutes to complete and is open to all.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

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Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

As 2025 comes to an end, host Dr. Nathaniel Chin discusses the importance of gratitude for brain health and shares what he’s grateful for from this past year.

Complete the Dementia Matters Feedback Survey to let us know what our show is doing well and how we can improve in the New Year! This anonymous survey will be open until January 14th, 2026 and is estimated to take about 5 minutes to complete.

Read the study Dr. Chin mentions at 0:57, “Association between gratitude, the brain and cognitive function in older adults: Results from the NEIGE study,” on the ScienceDirect website.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

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Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Traumatic brain injuries (TBI) like concussions are not uncommon, especially in children and older adults. These injuries can have both short-term and lasting effects on the brain, but what about their impact on cognitive function? Dr. Deling He of UW–Madison’s Cognitive-Communication in Aging and Neurogenic Disorders Laboratory (CCANDL) lab joins the podcast to discuss her research on the connections between TBI, speech pathology and cognition and what her study findings mean for people with a history of TBI.

Guest: Deling He, PhD, postdoctoral research associate, Cognitive-Communication in Aging and Neurogenic Disorders Laboratory, Department of Communication Sciences and Disorders, UW–Madison

Read the study from the University of California, San Francisco (UCSF), “Traumatic Brain Injury Strikes 1 in 8 Older Americans,” mentioned by Dr. Chin at 0:30 on the UCSF website.

Learn more about Dr. He’s study in the article, “TBI linked to long-term cognitive decline in preclinical Alzheimer’s disease,” published on Healio’s website.

Learn more about the Cognitive-Communication in Aging and Neurogenic Disorders Laboratory (CCANDL) on their lab website.

Learn more about Dr. He on the CCANDL website.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

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Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

When memory, thinking or communication changes begin, knowing where to turn for support can make all the difference. In this episode, we explore how two key health care specialties can help individuals and families meet those challenges with confidence. Sarah Gunderson, an occupational therapist, and Kari Esser, a speech-language pathologist, draw from their work supporting people experiencing a wide range of neurological conditions to walk us through the foundations of their specialties and their unique roles in mild cognitive impairment (MCI) and dementia care. Sarah and Kari also provide a preview of their upcoming talk, “Partnering with Your Healthcare Team,” as part of the 2025 Healthy Living with MCI education program.

Guests: Sarah Gunderson, OT, occupational therapist, UW Health, Kari Esser, MS, CCC-SLP, speech-language pathologist, UW Health

Register and learn more about the upcoming Healthy Living with MCI event featuring Dr. Chin, Sarah Gunderson and Kari Esser, happening on December 12, 2025, and future programs on our website.

Learn more about Sarah from her profile on the UW Health Website.

Learn more about Kari from her profile on the UW Health Website.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

What do COVID-19 brain fog and ophthalmology have to do with Alzheimer’s disease? There may be more connections than one might think. Dr. Sean Miller is one of the scientists behind a recent study that used retinal tissue to investigate the links between COVID-19 infections and the build-up of amyloid and other indicators of Alzheimer’s disease in the central nervous system. Dr. Miller joins the podcast to discuss his research and its implications for COVID and dementia diagnosis and treatments in the future.

Guest: Sean Miller, PhD, research scientist, department of ophthalmology and visual science, Yale School of Medicine, co-investigator, Logan Lab, Endicott College 

Read Dr. Miller’s study, “SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids,” on the journal Science’s website.

Learn more about Dr. Miller at his profile on the Yale School of Medicine website.

Read “Retinal pathological features and proteome signatures of Alzheimer's disease,” mentioned by Dr. Miller at 2:50, on the National Library of Medicine website.

Listen to our past episode, “Long COVID and Its Effect on Cognition,” on our website for more information on how COVID-19 can affect the brain.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Caring for someone living with dementia can be both deeply meaningful and incredibly challenging. Finding effective ways to connect, communicate and provide support often requires shifting how we see and respond to changes in the brain. In honor of National Family Caregivers Month, renowned dementia care specialist Teepa Snow joins the podcast to share her insights on improving life with dementia through empathy and understanding. As the founder of Positive Approach to Care (PAC), Teepa has developed the Snow Approach, a set of practical and compassionate techniques designed to empower care partners. She discusses the philosophy behind her methods, the importance of recognizing retained abilities and strategies that can make daily interactions more positive and meaningful for both care partners and those living with dementia.

Guest: Teepa Snow, MS, OTR/L, FAOTA, dementia care specialist, educator, owner, trainer, Positive Approach LLC, co-Founder & chair, Snow Approach Foundation

This episode was uploaded as an exclusive video episode on the Wisconsin ADRC YouTube page on November 5, 2025. Watch the video interview with Teepa Snow here.

Find videos, resources and more on Teepa Snow’s website.

Interested in hearing more from Teepa? Attend Dementia Friendly America’s (DFA) Dementia Friendsgiving on Tuesday, November 18, 2025, to hear her keynote talk on supporting people with dementia in dignified and respectful ways.

Learn more about lecanemab and the eligibility requirements from our past episode, “Looking at Lecanemab’s Eligibility Guidelines and Prescription Process,” on our website.

Learn more about grief and dementia from our past episode, “A Guide to Grief: Strategies for Navigating Loss and Dementia,” on our website.

Learn more about the National Council of Dementia Minds on their website.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Grief is a complex topic for people with dementia, their loved ones, caregivers and doctors to navigate. Dr. Erica Srinivasan, an expert on the psychology behind grief, joins the podcast to discuss the different kinds of grief people can experience and share strategies and resources for addressing the grief associated with dementia.

Guest: Erica Srinivasan, PhD, associate professor of psychology, University of Wisconsin–La Crosse (UWL), director, Center for Grief and Death Education, lead instructor, Grief Support Specialist Certificate, UW–Madison Continuing Education

Register for Dr. Srinivasan’s Grief Support Specialist Certificate course at the UW–Madison Continuing Education website.

Register for Dr. Srinivasan’s Dementia Support Specialist online courses course at the UW-La Crosse Extended Learning website.

Read more about Dr. Srinivasan at her profile on the UW–La Crosse website.

Listen to our episode “Shining Light on Younger-Onset Dementia with Lorenzo’s House,” mentioned by Dr. Chin at 14:19, on our website.

Learn more about MyGrief, the resource mentioned by Dr. Srinivasan at 22:42, on the Canadian Virtual Hospice’s website. 

Learn more about the UK Alzheimer’s Society, mentioned by Dr. Srinivasan at 23:04, on their website.

Learn more about Wisconsin’s Aging and Disability Resource Centers (ADRCs), mentioned by Dr. Srinivasan at 23:13, on the Wisconsin Department of Health Services website. Looking for resources outside of Wisconsin? Find local organizations using the Administration for Community Living’s (ACL) Eldercare Locator.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Clinical trials are essential for improving the lives of those diagnosed with Alzheimer’s disease and related dementias. With so many trials out there, it can be difficult for someone who’s interested in participating in research to know where to start. Dr. Jonathan Graff-Radford joins the podcast to discuss the ins and outs of clinical trials and the state of Alzheimer’s treatments today, as well as share some highlights from his presentation at the National Alzheimer’s Coordinating Center’s (NACC) 2025 Spring ADRC Meeting.

Guest: Jonathan Graff-Radford, MD, behavioral neurologist, associate professor, vice chair, Mayo Clinic Department of Neurology, co-investigator, Mayo Clinic Alzheimer’s Disease Research Center

Read more about Dr. Jonathan Graff-Radford at his profile on Mayo Clinic’s website.

Listen to part one and part two of our series on preclinical Alzheimer’s disease and the AHEAD study with Dr. Reisa Sperling, mentioned at 19:53, on our website.

Learn more about the AHEAD study on their website.

Learn more about clinical trials in Wisconsin at the UW Clinical Trials Institute's website.

Interested in participating in clinical trials? Visit clinicaltrials.gov or Alzheimer's Association's TrialMatch to learn how to get involved.

Learn more and register for the 2025 Fall Community Conversation: Addressing Hearing Loss for Better Brain Health on our website.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Microplastics are a growing concern in the field of environmental health, but their impact on the brain is only beginning to be understood. Joining the podcast to share the latest research on these tiny particles, which have been found in the brain and other parts of the body, is Dr. Matthew Campen, a leading researcher in the field whose work is helping to uncover how environmental exposures like the accumulation of microplastics could affect neurological health, dementia risk and more.

Guest: Matthew Campen, PhD, MSPH, director, New Mexico Center for Metals in Biology and Medicine, director, University of New Mexico Clinical and Translational Sciences Center KL2 Mentored Career Development Program, deputy director, Training Core director, UNM Metal Exposure and Toxicity Assessment on Tribal Lands in the Southwest (UNM METALS) Superfund Research Program Center, professor, University of New Mexico Health Sciences Center

Learn more about Dr. Campen and his research at his profile on the University of New Mexico website. 

Read Dr. Campen’s article, “Bioaccumulation of microplastics in decedent human brains,” published by Nature Medicine on Nature’s website.

Read “Nanoplastic concentrations across the North Atlantic,” the research article Dr. Campen mentioned at 23:08, on Nature’s website.

Read “The Story You’ve Been Told About Recycling is a Lie,” the opinion piece Dr. Campen mentioned at 25:40, on The New York Times website.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

As an individual develops dementia, they may need support in many areas of their lives. One of these areas is decision-making, particularly regarding health care decisions, but how can someone or their loved one determine if they need support with decision-making? To answer these questions, Dr. Victoria Williams joins to discuss capacity and capacity testing. She dives into the different kinds of decision-making abilities that can be assessed, the signs that one may need an assessment and more, as well as shares a preview of her upcoming Healthy Living with Mild Cognitive Impairment (MCI) program, “Cognitive Testing and Brain Imaging Explained.”

Guest: Victoria Williams, PhD, neuropsychologist, UW Health, assistant professor, Department of Medicine, University of Wisconsin School of Medicine and Public Health

Register and learn more about Dr. Williams’ upcoming Healthy Living with MCI event, happening on September 12, 2025, and future programs on our website.

Learn more about Dr. Williams at her bio on the UW Health website.

Listen to Dr. Williams’ past episode, “The Fundamentals of Neuropsychology: Breaking Down Cognition, Memory and More,” on our website, Spotify, Apple Podcasts and wherever you listen.

Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.