This podcast explores Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), a newly identified condition that primarily affects episodic memory while leaving other cognitive functions relatively intact. LANS is associated with the misfolding of TDP-43, a protein that can accumulate and damage limbic structures. Unlike Alzheimer’s, LANS has a slower onset and lacks definitive diagnostic tests, making research critical for future treatments. With the aging population, understanding and addressing LANS could become as significant as Alzheimer’s research. 

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References:

Morgane, P. J., et al. (2005). A review of systems and networks of the limbic forebrain/limbic midbrain. Progress in neurobiology, 75(2), 143-160. https://www.sciencedirect.com/science/article/pii/S030100820500002X

Catani, M., et al. (2013). A revised limbic system model for memory, emotion and behaviour. Neuroscience & Biobehavioral Reviews, 37(8), 1724-1737. https://www.sciencedirect.com/science/article/pii/S0149763413001711

Knopman, D. S., et al. (2021). Alzheimer disease. Nature reviews Disease primers, 7(1), 33. https://www.nature.com/articles/s41572-021-00269-y

Corriveau-Lecavalier, N., et al. (2024). Clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome. Brain Communications, 6(4).  https://academic.oup.com/braincomms/article/6/4/fcae183/7712717

Wolk, D. A., et al. (2024). Clinical criteria for Limbic‐Predominant age‐related TDP‐43 encephalopathy. Alzheimer's & Dementia, e14202. https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.14202

Nelson, P. T., et al. (2019). Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain, 142(6), 1503-1527. https://academic.oup.com/brain/article/142/6/1503/5481202

Tremblay, C., et al. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer dis

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For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com

Thank you for listening!