Philadelphia Eagles vs San Francisco 49ers Week 13 preview and predictions. The Philadelphia Eagles (10-1), after a thrilling overtime victory against the Buffalo Bills on Sunday, return to action against the San Francisco 49ers (8-3), who are coming off a victory on Thanksgiving, at Lincoln Financial Field on Sunday, December 3rd. The two teams meet again in a rematch of last season’s NFC Championship Game, where the Eagles dominated the Niners 31-7. The Eagles are 2.5-point home underdogs and the over/under is set at 47.5 points. Jalen Hurts, AJ Brown, DeVonta Smith, and the Eagles vs Brock Purdy, Deebo Samuel, George Kittle, and the 49ers… who wins? The panel will give their thoughts on NFL Week 13, and give their picks for the week. Meanwhile, the panel will give their thoughts on the showdown between the Philadelphia 76ers and New Orleans Pelicans.