In this episode, we break down one of the most vital yet challenging topics in nursing—acid-base balance. We’ll review the foundational concepts of acids, bases, and pH regulation, exploring how the body maintains homeostasis through its buffer systems, including the rapid respiratory response and the slower but powerful renal system. You’ll learn to recognize and differentiate the four primary imbalances—respiratory acidosis, respiratory alkalosis, metabolic acidosis, and metabolic alkalosis—along with their causes, clinical manifestations, and treatments, such as improving ventilation or administering bicarbonate. We’ll also walk through interpreting Arterial Blood Gas (ABG) results and calculating the Anion Gap to pinpoint underlying issues. With real-world clinical examples, this episode will help you confidently assess, interpret, and intervene when acid-base disturbances arise.