Adding Years

❤️ Thanks to Humann for sponsoring Adding Years! Explore their heart health supplements at https://humann.com/josie and use code JOSIE15 for 15% off your order!

In this episode of Adding Years, I sit down with Dr. Andy Galpin, a leading expert in human performance and exercise science, for a conversation that challenges some of the conventional advice surrounding fitness and longevity.

Andy shares why he rarely changes a workout based on daily wearable data, why being strong doesn't necessarily mean you're physically fit, and why identifying your biggest limitation may be more valuable than trying to improve everything at once. What I particularly enjoyed about this conversation was Andy's willingness to challenge the idea that more data, more optimization, and more discipline always lead to better outcomes. It's a refreshing perspective on exercise that shifts the conversation away from perfect routines and toward making better decisions about our health.

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests or co-hosts may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

What if we could replace the cells we lose to aging and disease AND make those replacements from our own cells? Dr. Nabiha Saklayen, co-founder and CEO of Cellino, joins us on Adding Years to explore personalized regenerative medicine: the science behind it, the challenge of manufacturing it, and the evidence still needed to understand its potential.

In this episode we discuss:

• Preserving struggling cells versus replacing lost cells

• Yamanaka factors and induced pluripotent stem cells

• Genetics, gene editing, and the limits of an epigenetic reset

• The challenges of replacing cells in an aging body

• Autologous versus allogeneic cell therapies

• How AI and lasers support cell selection and manufacturing

• Manufacturing costs, access, and the vision of personalized cell banking

• Questions to ask when evaluating regenerative medicine claims

This conversation distinguishes today’s research and clinical development from the broader vision of widely accessible cell replacement. Subscribe for more conversations with researchers and innovators shaping the future of health and longevity.

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests or co-hosts may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

What happens when we get the right answer to the wrong question? In this episode of Adding Years, Josie sits down with Dr. Jordan Shlain, physician, healthcare entrepreneur, and founder and chairman of Private Medical. Together, they explore:

• How to separate credible longevity science from a compelling sales pitch

• Why smart, successful people still fall for health and longevity hype

• Peptides, stem cells, exosomes, and interventions ahead of the evidence

• Why foundational health behaviors continue to matter

• Whether we’re measuring our health simply because we can

• When optimization creates more anxiety than benefit

• The difference between processing medical information and practicing medicine

• Where AI can strengthen healthcare—and where human judgment remains essential

• Why asking the right question may matter more than finding a fast answer

As Dr. Shlain explains, data does not interpret itself. The meaning of any number, test, or recommendation depends on the person, the context, and the question we are actually trying to answer. Are we using technology to make better health decisions—or are we simply finding more things to optimize?

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests or co-hosts may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

Is more protein really better for healthy aging—or could eating less protein help us live longer? In this episode, Dr. Matt Kaeberlein joins me as co-host to examine some of the most debated and emerging areas of longevity science. Matt is a leading researcher in the biology of aging whose work has explored interventions that may improve healthspan and extend lifespan.

We explore:

• Whether high-protein diets are supported by longevity research • The potential tension between preserving muscle and extending lifespan

• Why the effects of protein depend on calories, diet quality, exercise and age

• What studies in mice can—and cannot—tell us about protein restriction in humans

• How specific amino acids interact with mTOR and other aging pathways

• What FGF21 is and why it may mediate some effects of protein restriction

• New research using FGF21 gene therapy to extend healthspan and lifespan in mice

• Whether existing interventions could offer similar benefits with less risk

• How Montana’s expanded Right to Try framework approaches experimental therapies

• The challenge of balancing patient access, scientific evidence and safety

Whether you’re focused on building muscle, improving metabolic health or living longer, this conversation offers a more nuanced way to think about protein—and a look at where longevity research may be heading next.

Read Lamming's paper: https://www.cell.com/cell-press-blue/fulltext/S3051-3839(26)00077-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS3051383926000770%3Fshowall%3Dtrue

Read about FGF21 gene therapy: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(26)00469-7

Read Montana’s expanded Right to Try: https://montanabio.org/sb535-right-to-try-montana/

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests or co-hosts may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

What separates evidence-based supplements from clever marketing—and what does the science really tell us about longevity?

In this episode, I sit down with Dr. Leonard “Lenny” Guarente, MIT professor and co-founder and chief scientist of Elysium Health. Dr. Guarente is a pioneer in aging research whose work helped establish the connection between sirtuins, metabolism, and longevity.

We explore:

• How to evaluate the quality of a supplement

Whether you’re curious about supplements, healthy aging, or the emerging science of longevity, this conversation offers a practical framework for evaluating claims and following the evidence.

Learn more about Dr. Guarente’s research:

Explore Elysium Health’s published research and clinical trials:

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

In this episode of Adding Years, we sit down with orthopedic surgeon Dr. Farzin Kabaei to explore why joint health deserves a more prominent place in the longevity conversation.

We discuss why arthritis or degeneration on an X-ray does not always translate to pain, why imaging alone should not determine your future, and how strength, mobility, and individualized movement can help you remain active as you age.

In this conversation, you’ll learn:

• Why “wear and tear” does not tell the full story of joint health

Living longer is only part of the goal. The ability to move, remain independent, and participate fully in life is what makes those additional years meaningful.

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

What if curing every cancer only added 2.5 years to your life but slowing aging itself could add 20 to 30? That's where this conversation with aging scientist Dr. Matt Kaeberlein begins, and it doesn't let up. We cut through the longevity noise to separate what actually moves the needle from what's just good marketing: the hallmarks of aging, the real story on rapamycin, why "natural" doesn't mean safe, how to spot a longevity doctor worth trusting, and what a study of 55,000 dogs is quietly teaching us about how to live longer. Whether you're deep in the longevity world or just tired of being sold the next miracle supplement, this episode gives you a framework to think for yourself.

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.

In this episode of Adding Years, I’m joined by Dr. Rhea Kotecha to explore the gut-metabolism connection and how gut health shapes blood sugar, energy, hormones, and the way we age. We break down what metabolic health actually means, why standard bloodwork may miss early signs of metabolic dysfunction, and how symptoms like waking up tired, crashing after meals, constant hunger, sugar cravings, and poor sleep may be connected to insulin resistance and poor metabolic flexibility. Dr. Rhea explains how the gut microbiome influences glucose regulation, inflammation, GLP-1 production, satiety, and hormone signaling. We also discuss whether probiotics and prebiotics are really worth it, why food and fiber are still foundational for gut health, and how modern lifestyles are disrupting our natural rhythms. In this conversation, we cover: * What poor metabolic health really means * The early signs of insulin resistance * Why fasting glucose and HbA1c may not show the full picture * How gut health and blood sugar are connected * The role of GLP-1, fiber, and the microbiome * Probiotics, prebiotics, and gut health marketing * Visceral fat, fatty liver, and cardiovascular risk * How cortisol, stress, sleep, and meal timing affect metabolism * Why eating earlier may improve glucose response and recovery * How emotional health and social connection impact longevity If you’re interested in longevity, metabolic health, gut health, blood sugar, insulin resistance, hormone health, glucose spikes, GLP-1, microbiome health, or how to improve energy and healthspan, this episode will help you understand how these systems are all connected. Subscribe to Adding Years for more conversations on longevity, healthspan, metabolic health, women’s health, gut health, hormones, nutrition, and the science of aging.

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.  

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.  

The information provided in Adding Years: Your Roadmap to Longevity is for informational and educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. The hosts and producers are not licensed medical professionals, dietitians, or healthcare providers. While some guests may be licensed medical professionals, they appear solely in an educational capacity and are not providing individualized medical care or establishing any healthcare provider–patient relationship.