This episode of the Dementia Researcher Podcast continues our coverage from the AD PD Conference 2026 in Copenhagen, one of the largest international meetings focused on Alzheimer’s and Parkinson’s disease.

Hosted by Professor Louise Serpell, the conversation brings together Athina Grigoriou, Dr Lauren O’Neill, and Dr Sofie Let Frandsen, each sharing highlights from across the conference.

The discussion spans a wide range of topics, from the biological role of alpha synuclein and mitochondrial dysfunction, through to emerging therapeutic targets and the growing importance of biomarkers. There is a strong focus on how diseases are more complex and varied than once thought, with increasing attention on stratification, personalised medicine, and early detection.

Alongside the science, the episode also reflects on the importance of patient voices, collaboration across disciplines, and the value of sharing both positive and negative research findings.

This is Part Two of our AD PD 2026 reflections, offering a thoughtful look at where the field is heading next.

ADPD Conference Website - adpd.kenes.com/

Top Takeaways:

• Alpha synuclein may have a normal physiological role, not just a pathological one
• Mitochondrial dysfunction remains central in Parkinson’s mechanisms
• Biomarkers are key for both early detection and patient stratification
• Diseases like Parkinson’s and dementia are highly heterogeneous
• Personalised medicine is becoming a realistic goal, not just an idea
• New therapeutic targets beyond dopamine are emerging
• Early stage and presymptomatic intervention is a major focus
• Patient and carer perspectives remain underrepresented but essential
• Collaboration and openness, including sharing negative results, are vital
• More diverse populations are needed to validate biomarkers globally

A transcript of this show, links and show notes and profile on all our guests are available on our website at www.dementiaresearcher.nihr.ac.uk

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