On the final episode of 2025, host Erin Welsh is joined by Courtney Allison, host of NewYork-Presbyterian’s health and wellness podcast, Health Matters, to recap the year’s highlights from their dozens of conversations with clinicians, researchers, and health care specialists from Columbia & Weill Cornell Medicine. They highlight key takeaways, revisit groundbreaking treatments that were pioneered across the institution, and discuss several research updates that are shaping the future of medicine for both physicians and patients.  

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For any patient diagnosed with depression for the first time, the recommended course of treatment is the same: a medication like a selective serotonin reuptake inhibitor (SSRI), an evidence based psychotherapy, or both. But there is a large group of people for whom these treatments simply won't work. That’s where Dr. Conor Liston and his team focus. In this episode from the Advances in Care archives, Dr. Liston speaks with former host Catherine Price about his work mapping the brain is helping doctors better understand where depression is impacting certain brain structures and what that means for the symptoms patients present. Dr. Liston’s work is focused on identifying how these symptoms impact patients' brains and using those findings to identify the best treatment approach.

Since this episode aired, Dr. Liston and his colleagues have continued to build on their research regarding a specific region of the brain called the “salience network.” They found that the salience network was considerably larger in people with clinical depression than in those without, and that people with larger salience networks in childhood were more likely to develop depression later in life. Their research points to an enlarged salience network as the first objective biomarker for diagnosing depression, which could revolutionize how depression is treated, and allow for intervention even before symptoms develop.

In this episode from the Advances in Care archives, Dr. Pierre Elias sits down with Catherine Price to talk about how utilizing technologies like artificial intelligence and machine learning can help diagnose patients even before symptoms develop, and support doctors by freeing them up to focus on providing personalized care to their patients. They discuss navigating bias in both artificial intelligence and clinical care, and how new technology will improve the future of medicine.

Since this episode aired, Dr. Elias and his collaborators expanded their research involving AI and cardiac care, developing tools for detecting mitral regurgitation and heart failure.

Additionally, a team at NewYork-Presbyterian and Columbia used AI as a fertility treatment for azoospermia, and NewYork-Presbyterian deepened its commitment to developing applications of AI in medicine through a $2 billion campaign to invest in talent and technology.

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With perspectives spanning hepatobiliary, gynecologic, and cardiac surgeries, NewYork-Presbyterian’s Dr. Jason Hawksworth (Columbia), Dr. Tamatha Fenster (Weill Cornell Medicine), and Dr. Arnar Geirsson (Columbia) describe how they each came to incorporate robotics into their practices. One of the biggest takeaways: robotic surgeries allow for more accuracy in minimally-invasive approaches; so patients experience shorter hospital stays and quicker recoveries, even after major procedures. But there are some limitations to robotic surgeries that the doctors are still navigating. Dr. Fenster discusses how there are haptics limitations in robotic surgery. As a result, she shares more about her innovative smartHER 3D MRI program that is addressing this issue and details how her and her team are developing a way of holographically projecting 3D MRIs over patients to help guide surgeons while they operate.

Since this episode aired, a team at Weill Cornell Medicine performed the first fully robotic liver transplant in the state of New York, and the Robotic Cardiac Surgery Program at NewYork-Presbyterian and Columbia completed over 100 robotic heart surgeries. Additionally, Dr. Tamatha Fenster put smartHER 3D MRI technology into practice.

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Catherine Price and Dr. Emile Bacha, Chief of the Division of Cardiac, Thoracic, and Vascular Surgery at NewYork-Presbyterian/Columbia discuss the history of heart surgery, ventricular assist devices, and a new frontier in cardiac surgery: The Total Artificial Heart. Dr. Bacha tells the groundbreaking story of successfully fitting a pediatric patient with a Total Artificial Heart. He explains the nuances of the procedure, and how a backpack-powered heart gave his pediatric patient another chance.

In 2023, Dr. Bacha led a team to complete the first domino infant partial heart transplant in the world. Surgeons in his division also completed the first split-root domino transplant in the northeast, saving the lives of three young patients. Most recently, Dr. Bacha became the 106th president of the American Association for Thoracic Surgery.

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Dr. Chris Ahmad knows firsthand how devastating an untimely injury can be for a young athlete. In this episode from the Advances in Care archives, Dr. Ahmad discusses how his own college soccer injury led him to fall in love with orthopedics. He tells the history of the infamous baseball injury that resulted in the invention of Tommy John surgery, and shares how he learned to perform the corrective procedure from the man who designed it. Dr. Ahmad chronicles his endeavors to innovate orthopedic surgery and get athletes back onto the field stronger – both physically and mentally.

Since this episode aired, Dr. Ahmed and his colleagues at NewYork-Presbyterian have taken Tommy John surgery to new heights. They’ve introduced an innovative approach to the procedure called Triple Tommy John Surgery, or TJ3. TJ3 combines ULC repair with reconstruction techniques, offering faster recovery with fewer setbacks and better career longevity for these world class athletes.

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On this episode of Advances in Care, we return to the high-intensity environment of New York City’s emergency departments with Dr. Angela Mills and Dr. Brenna Farmer. Host Erin Welsh hears from these leaders at NewYork-Presbyterian about how they are implementing innovative strategies to meet the challenges of the behavioral health emergencies epidemic.

Dr. Brenna Farmer, chief of emergency medicine at NewYork-Presbyterian Brooklyn Methodist, and Dr. Angela Mills, chief of emergency medicine at NewYork-Presbyterian and Columbia, bring us inside the emergency departments they lead to explain the challenges that their staff face in meeting the needs of severely decompensated patients. From disruptions in the flow of care, to potentially violent outbursts, their teams navigate these issues against the backdrop of an already complex operational environment.

Dr. Farmer tells us how she has implemented an innovative protocol called BERT– the Behavioral Health Response Team– in the Brooklyn Methodist Emergency Department, which is rolling out across the NewYork-Presbyterian system. BERT allows ED teams to better address  behavioral health patients, leading to more robust support for staff, and quicker, more comprehensive patient care overall, including connecting them to much needed outpatient resources. Finally, Dr. Farmer and Dr. Mills share additional strategies they employ to support their own well-being– and that of their medical teams– as they face difficult cases, plus their personal reasons for working in this unique field.

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Dr. Angela M. Mills is a nationally recognized leader and expert in emergency medicine. She serves as the inaugural chair of the newly designated Department of Emergency Medicine at Columbia University Irving Medical Center and chief of Emergency Medicine Services at NewYork-Presbyterian. 

Dr. Brenna M. Farmer is Chief of Emergency Medicine at NewYork-Presbyterian Brooklyn Methodist Hospital and vice chair for the Department of Emergency Medicine at Weill Cornell Medicine. She is also an assistant associate professor of clinical emergency medicine at Weill Cornell Medicine. Dr. Farmer is a nationally recognized medical toxicology expert and frequent keynote speaker on quality improvement, patient safety, and medication safety.

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On this episode of Advances in Care, host Erin Welsh hears from two emergency department chiefs at NewYork-Presbyterian about how they optimize operations in their uniquely high-intensity, high-volume EDs.

Dr. Angela Mills, chief of emergency medicine at NewYork-Presbyterian and Columbia, and Dr. Brenna Farmer, chief of emergency medicine at NewYork-Presbyterian Brooklyn Methodist, both lead large medical teams in high-volume, New York City emergency departments. They discuss what makes New York City such a unique environment for emergency care, from its massive population and cultural complexity, to the severity and array of traumas that can come through the ED doors each day. Then, they share stories behind the life-saving care they provide, and explain why the collaborative spirit and excitement of the emergency room keeps them coming back to work every day.

Dr. Mills and Dr. Farmer also describe some of the ways that they continuously optimize operations in their departments, including addressing language barriers and providing specialized care for patients with complex cardiac needs. Their goal is to ensure that their staff can navigate the organized intensity of the emergency medicine environment without missing a beat.

In our next episode, Dr. Mills and Dr. Farmer return to discuss how their departments are piloting innovative strategies to address the growing behavioral health epidemic that is affecting EDs across the country.

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Dr. Angela M. Mills is a nationally recognized leader and expert in emergency medicine. She serves as the inaugural chair of the newly designated Department of Emergency Medicine at Columbia University Irving Medical Center and chief of Emergency Medicine Services at NewYork-Presbyterian. 

Dr. Brenna M. Farmer is Chief of Emergency Medicine at NewYork-Presbyterian Brooklyn Methodist Hospital and vice chair for the Department of Emergency Medicine at Weill Cornell Medicine. She is also an associate professor of clinical emergency medicine at Weill Cornell Medicine. Dr. Farmer is a nationally recognized medical toxicology expert and frequent keynote speaker on quality improvement, patient safety, and medication safety.

For more information visit nyp.org/Advances.

When her own experience with a complicated pregnancy reignited an interest in medicine and science, Dr. Lauren Osborne left her career in publishing to pursue medical school. Now a reproductive psychiatrist, Dr. Osborne leads the way in researching the connection between immune system dysregulation, stress reactivity, and the role of allopregnanolone in mood and anxiety disorders, particularly in pregnant and postpartum women. In this episode from the Advances In Care archives, she discusses how her expansive research is getting us one step closer to decoding perinatal mood disorders, and she calls for increased training in reproductive psychiatry to help OBGYNs better treat their patients.

Since this episode aired Dr. Osborne and her colleagues have taken their research on perinatal mood disorders one step further. They conducted the first comprehensive study of the metabolic pathway of the hormone progesterone to pinpoint alterations that could predict which women are at a higher risk of postpartum depression, or PD. They are hopeful that their findings will lead to the development of a blood test that could be used during pregnancy to predict PD and identify which patients may benefit from prophylactic treatment.

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On this episode of Advances in Care, host Erin Welsh speaks with Dr. Zev Williams, Chief of the Division of Reproductive Endocrinology and Fertility at NewYork-Presbyterian and Columbia and Director of the Columbia University Fertility Center. Recently, Dr. Williams and a team of researchers and clinicians used artificial intelligence to develop a system called STAR, or Sperm Track and Recovery, which combines advanced imaging with innovations in microfluidic chip technology to more accurately identify and capture sperm in samples from patients with azoospermia – a condition that often leaves men with untraceable numbers of sperm in their semen.

Dr. Williams explains that some azoospermia patients might have two or three sperm cells as opposed to the typical two or three million and having human researchers looking for those cells under a microscope is painstaking and rarely leads to success. Inspired by the AI-powered technology that astrophysicists use to find stars, Dr. Williams and his colleagues set out to build a tool that could help embryologists not only find those few sperm in a field of cell debris, but also collect them gently for future fertilization in an expedited manner.

The effort took five years of research and development, along with a collaborative bench-to-bedside research approach that Dr. Williams says is unique to the Columbia University Fertility Center. But the work paid off, resulting in a successful pregnancy and a promising example of how AI will continue to transform reproductive medicine.

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Dr. Zev Williams is the Wendy D. Havens Associate Professor of Women's Health at Columbia and the Chief of the Division of Reproductive Endocrinology and Infertility at NewYork-Presbyterian Columbia University Irving Medical Center. As a physician scientist, Dr. Williams' focus has been on helping those suffering from recurrent pregnancy loss and infertility and developing novel technologies and treatments to improve patient success.

For more information visit nyp.org/Advances