This episode applies risk based lipoprotein targets across specific clinical scenarios for atherosclerotic cardiovascular disease risk reduction. It highlights how severe hypercholesterolemia, diabetes, subclinical atherosclerosis, hypertriglyceridemia, and clinical ASCVD are stratified using the same three tier framework of 100/130/90, 70/100/70, and 55/85/55. It emphasizes the role of coronary artery calcium in refining risk, the use of apoB to assess atherogenic particle burden, and the distinction between patients with and without established ASCVD. It also reinforces that diabetes without ASCVD does not meet criteria for the most intensive targets and that consistent numeric thresholds guide management across varying clinical presentations.