Alexander Disease Research Update

Albee Messing’s presentation at the recent Alexander disease conference in Philadelphia, August 3, 2024. 

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

Albee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications: 

[02:07]       A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging

                  Paediatric Anesthessia (in press) 

[10:17]       Glial fibrillary acidic protein is pathologically modified in Alexander disease

                  Journal of Biological Chemistry (in press) [full text]

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging

Paediatric Anaesthesia, (in press) (2024)

Glial fibrillary acidic protein is pathologically modified in Alexander disease

Journal of Biological Chemistry, (in press) (2024)

Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: 

[02:02]       Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease         

Neurological Sciences (2024)  [full text]

[04:16]       Discussion about Philadelphia Conference, August 2-4, 2024   

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

Albee Messing and Linghai Kong discuss the following recent publication: 

[01:52]       3D bioprinting of human neural tissues with functional connectivity. 

Cell Stem Cell 31:260-274.e7 (2024) [full text]

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

J Vis Exp, 18, 55655 (2017)

STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

Cells, 12, 978 (2023)

A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells

Stem Cell Reports, 18, 1701-1720 (2023)

Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: 

[00:59]       Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN)

Molecular Biology of the Cell (in press)

[full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/]

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

            https://alexander-disease.waisman.wisc.edu/donate/

Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: 

[4:30]          Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press

[15:11]        Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcomes in Cerebral Alexander Disease. 

Journal of Child Neurology (2023) in press

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: 

[01:45]       A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells

                  Stem Cell Reports 18, 1701-1720 (2023)

[includes new iPS cell line from an individual with Alexander disease] [full text]

[05:39]       Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Journal of Visualized Experiments 18, 55655 (2017)

[includes data on acetylation of lysines in GFAP] [full text]

[10:26]       STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

                  Cells 12, 978 (2023)

[identification of one of the key mechanisms responsible for the increase in GFAP levels in Alexander disease] [full text]

[22:35]       Questions from email: does Alexander disease affect menstrual cycles?

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

Webinar on the strategy and preliminary results for “AAV-mediated Gene Silencing for the Treatment of Alexander Disease” presented by Drs. Guangping Gao, Jun Xie, and Dominic Gessler from the University of Massachusetts Medical School. 

This version is audio only - the full video version will be made available later at a site that is not yet determined.

Albee Messing and Davide Tonduti discuss the following recent publication: 

[00:41]       Type I Alexander Disease: Update and Validation of the Clinical Evolution-Based Classification
Molecular Genetics and Metabolism 138, 107540, 2023

 [16:01]       Questions from email regarding mesenchymal stem cells for transplantation and the intranasal route for delivering therapeutics to the central nervous system. 

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/

Albee Messing and Josh Bonkowsky discuss the following recent publication: 

[02:13]       Identification of a novel de novo pathogenic variant in GFAP in an Iranian family with Alexander disease by whole-exome sequencing.European Journal of Medical Research  27, 174 (2022) [full text]

[14:20]       Questions from email regarding the brainstem in Alexander disease.

Send your questions and feedback to:  [email protected]

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

          https://alexander-disease.waisman.wisc.edu/donate/