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Alexander Disease Research Update
Alexander Disease Research Update episodes
- Alexander Disease Research Update, Episode #36: What is Atypical Parkinsonism and Why is that Sometimes Confused with AxD?
Feedback and questions are welcome!
Albee Messing and Abby Olsen discuss the following recent publication:
Adult-Onset Alexander Disease Presenting as Atypical Parkinsonism and Autonomic Dysfunction: A Case Series
Journal of Clinical Medicine, 15, 5677 (2026)
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)
#alexanderdisease
#alexanderdiseaseresearch
23 min - Alexander Disease Research Update, Episode #35: When a Doctor is a Patient
Feedback and questions are welcome!
Albee Messing and Aidan Long discuss the following recent publication:
Demonstrating clinical and radiological variability of adult-onset Alexander disease in three siblings
Journal of the Neurological Sciences 489, 126109 (2026)
https://pubmed.ncbi.nlm.nih.gov/42501499/
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)
#alexanderdisease
#alexanderdiseaseresearch
28 min - AxDRU Episode #34: AxD rats have problems with eating and speaking
Feedback and questions are welcome!
Albee Messing, Jared Cullen, and Nadine Connor discuss the following recent publication:
Behavioral characterization of bulbar sensorimotor function in a rat model of Alexander disease
Behavioural Brain Research (in press)
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)
#alexanderdisease
#alexanderdiseaseresearch
28 min - Alexander Disease Research Update – Episode #33: Can Initial MRI and Two Motor Milestones Predict Trajectory of Disease?
Feedback and questions are welcome!
Albee Messing and Ylenia Vaia discuss the following recent publication:
Neuroradiological patterns and prognostic implications in type I Alexander disease
Molecular Genetics and Metabolism, 148, 110189 (2026)
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)
25 min - Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes
Feedback and questions are welcome!
Albee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications:
Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.
Redox Biology 92:104103 (2026)
Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.
Free Radical Biology & Medicine (in press)
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
Podcasts are supported by Daniel's Fight (https://www.danielsfight.com)
33 min - Alexander Disease Research Update – Episode #31: 1) Development of an AxD Severity Score, and 2) Peer review – please come home
Feedback and questions are welcome!
Albee Messing, Annette Bley, and Nadia Kokaly discuss the following recent publication:
[01:58] Description of the Hamburg Alexander Leukodystrophy Cohort-Insights into Practical Classification and the Care Situation.
Journal of Clinical Medicine 14, 6918 (2025)
[19:00] Comment: Peer review – please come home.
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
Podcasts are supported by Daniel's Fight (https://www.danielsfight.com).
23 min - Alexander Disease Research Update – Episode #30: 1) Speech-language impairments, and 2) GFAP concentrations in CSF and blood
Feedback and questions are welcome!
Albee Messing, Debra Levin, and Amy Waldman discuss the following recent publications:
[01:27] Language Skills in Patients With Alexander Disease.
American Journal of Speech-Language Pathology 35:211-225 (2025)
[17:06] Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease.
Annals of Clinical and Translational Neurology (in press) [full text]
Send your questions and feedback to: [email protected]
Podcasts supported by Daniel's Fight.
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
29 min - Alexander Disease Research Update - Episode #29: Genotype-phenotype correlations, or does variant predict course?
Feedback and questions are welcome!
Albee Messing and Amanda Nagy discuss the following recent publication:
[01:42] Genotype-phenotype correlations of GFAP variants in type I Alexander disease subtypes
Molecular Genetics & Metabolism 147, 109689 (2026)
Please send questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
15 min - Alexander Disease Research Update - Episode #28: GDF15, nausea, vomiting, and "failure to thrive"
Feedback and questions are welcome!
Albee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication:
[01:45] Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease
Annals of Clinical and Translational Neurology (in press) [full text]
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
27 min - Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants
Feedback and questions are welcome!
Albee Messing, Mel Feany, and Natasha Snider discuss the following recent publication:
Genotype-phenotype association for 14 GFAP variants in Alexander disease.
Neurology: Genetics. 11, e200270 (2025) [full text]
Send your questions and feedback to: [email protected]
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
https://alexander-disease.waisman.wisc.edu/donate/
1. Berman RF, Matson MR, Bachman AM, Lin N-H, Coyne S, Frelka A, et al. GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease. eNeuro:(in press) (2025)
PMID: 40064497
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
J Vis Exp, 18, 55655 (2017)
STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease
Cells, 12, 978 (2023)
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
Stem Cell Reports, 18, 1701-1720 (2023)
33 min
About Alexander Disease Research Update
From the publisher's feed
Discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.