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In this episode we talk about the three ways to make AI "medical", fine-tuning, retrieval, and prompting, what each one actually does, and how to tell them apart when a vendor is selling to you. Plus why a general model, prompted well, beat the specialized medical one.
Paper: Nori H, et al. Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine. arXiv:2311.16452. 2023.
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
In this episode we talk about training vs. using - how these models are built, why they have a knowledge cutoff, and why they never actually learn from your corrections no matter how many times you correct them.
Paper: Singhal K, et al. Large language models encode clinical knowledge. Nature. 2023;620(7972):172-180.
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
This episode: Why a prompt isn't a request but a set of conditions, why "be accurate" accomplishes nothing, and why letting a model say "I don't know" is the highest-leverage move you can make.Paper: Pandit S, et al. MedHallu: A Comprehensive Benchmark for Detecting Medical Hallucinations in LLMs. EMNLP 2025.
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
This episode: retrieval-augmented generation - giving the model a library instead of a memory.
Paper: Zakka C, et al. Almanac — Retrieval-Augmented Language Models for Clinical Medicine. NEJM AI. 2024;1(2).
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
This episode: hallucination. The model produces a correct answer and a completely fabricated one by exactly the same process.
Paper: Pal A, et al. Med-HALT: Medical Domain Hallucination Test for Large Language Models. CoNLL 2023.
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
In this episode we talk about tokens and context - the model's working memory. What's in it, what falls out, why long chats degrade, and why a bigger context window is not the same as a bigger attention span.
Paper: Liu NF, et al. Lost in the Middle: How Language Models Use Long Contexts. TACL. 2024;12:157-173.
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
what actually happens in the seconds after you hit enter after typing your prompt.
Paper: Goh E, et al. Large Language Model Influence on Diagnostic Reasoning: A Randomized Clinical Trial. JAMA Netw Open. 2024;7(10):e2440969.
Substack: https://algoadipose.substack.com
Music credit: NCS Dream – Di Young
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