Dr. Jerrold Rosenbaum is the Chief of Psychiatry at Massachusetts General Hospital, a Professor of Psychiatry at Harvard and is recognized as one of the leading authorities in mood and anxiety disorders. He is the chair of the board of the American Foundation for Suicide Prevention and as a part of mental health awareness month I am honored to have him on the show. We talk about antidepressants vs. placebo, the difference between SSRIs, SNRIs and NDRIs, Ketamine as an option for treatment-resistant depression, the role of exercise, inflammation and the gut microbiome in depression/anxiety and what makes him optimistic about the future of psychiatry. This episode is packed with information and Dr. Rosenbaum does a phenomenal job at clarifying some of the misinformation and contradictory information on the internet regarding psychiatry through his expertise from 45 years of being a leader in the field.