Why is it that individuals who are hospitalized often leave the hospital with decreased mobility and functional abilities? In this episode of Clinically Significant™, host Maylyn Martinez, MD, MSc explores the causes, diagnosis, and treatment of Hospital-acquired disability (HAD). Are fall prevention efforts helping or harming hospitalized patients? Can societal norms and public health policies shift away from bed rest and encourage safe mobility for patients with acute medical illness? Tune in for the answers to these questions and actionable steps health care providers can take to prevent HAD.

Ths activity is comprised of five multiple-choice questions based on the content of an AMA Journal of Ethics podcast patient experiences with chronic pain and how physical therapy can be used for good migraine headache care. Featured guests are Kim Christiansen, RN, a nurse and lactation consultant who works at AMITA Health Resurrection Medical Center in Chicago, Il and Natalie Hoff, PT, DPT, a physical therapist at the Diamond Headache Inpatient Clinic at AMITA Health Saint Joseph Hospital in Chicago, Illinois. The target audience for this activity includes clinicians of all specialties as well as other health care professionals.

Artificial intelligence is reshaping how clinicians think and care for patients. In our conversation with Jonathan Chen, MD, PhD, Associate Professor of Medicine and Biomedical Data Science at Stanford University, he shares how AI has enhanced his own clinical work and the practical steps that foster trust and adoption among clinicians. The discussion goes beyond technology to explore the emotional dimensions of care, address bias, and outline the safeguards needed to use AI responsibly. We also review AI's impact on medical education and the evolving hospital landscape for responsible, future-ready AI-enabled care. Join us for a thoughtful exploration of the promise, challenges, and path forward to integrate AI into clinical decision making.

Nursing is at a pivotal moment and bold leadership is shaping what comes next. Join Dale E. Beatty, DNP, RN, Chief Nurse Executive and Senior Vice President at Stanford Health Care, for a candid conversation on the future of nursing practice and education. Drawing from his experience leading system-wide transformation, Dr. Beatty reflects on workforce challenges, the evolving role of nurse leaders, and what it truly takes to build cultures where care, innovation, and people thrive. This discussion offers a forward-looking perspective on how nursing can move beyond resilience toward redesign—reimagining education, leadership, and mentorship to meet the demands of modern healthcare.

How can clinicians effectively manage pain while mitigating the risks of opioid misuse and overdose? In this episode, Amanda Latimore, PhD, discusses opioid therapy with experts Jarratt Pytell, MD, and Arianna Campbell, MPH, PA-C, to address this critical question. Topics include assessing patient risk, clinical decision-making for prescribing opioids, safe prescribing and monitoring, patient education; and personalized, long-term care. By tuning in, listeners will gain valuable insights on how to manage pain while ensuring patient safety.

In this episode, hosts Ashley Cooper and Sub Krishnamurthy sit down with Dr. Kriti Prasad and Dr. Khaalisha Ajala to talk about the heavy toll of clinician burnout, how it intersects with racial inequities in healthcare, and why reclaiming rest needs to be treated as both a personal and systemic priority. Together, they explore how exhaustion, moral injury, and structural racism are intertwined, and how these forces not only affect providers but also shape patient outcomes. The conversation explores both big-picture policy solutions and practical steps for everyday advocacy and healing.

Pain management requires a multimodal, patient-centered approach. In this episode, Amanda Latimore, PhD, and guests Jarratt Pytell, MD, and Arianna Campbell, MPH, PA-C, discuss comprehensive pain management strategies. Topics include opioid and non-opioid medications, short-acting opioids for acute pain, and nonpharmacologic therapies—with an emphasis on aligning treatment with patient goals; and the importance of communication, trust, and respect in patient care. By tuning in, listeners will gain essential insights into effective and safe pain management.

In this inaugural episode of our limited podcast series on navigating pain management dilemmas and opioid use risks in today's healthcare landscape, Amanda Latimore, PhD, Jarratt Pytell, MD, and Arianna Campbell, MPH, PA-C, introduce Risk Evaluation and Mitigation Strategies (REMS). They address misconceptions about pain and opioid risks, discuss safe prescribing strategies aligned with updated CDC guidelines, and emphasize the importance of patient education in preventing addiction and overdose.

In a rapidly evolving healthcare landscape, the intersection of technology and medicine is paving the way for groundbreaking advancements. Join us for a conversation with Dr. Jessica Mega, a Cardiologist at Stanford and a pioneer in precision health. Dr. Mega shares her insights on the transformative potential of precision medicine and artificial intelligence in diagnostics, as well as the challenges that lie ahead. Discover how interdisciplinary collaboration among engineers, data scientists, and clinicians is driving innovation, and learn about the vital role of precision medicine in preventive care and population health. With a focus on preparing the next generation of clinicians, Dr. Mega offers guiding principles for fostering innovation in health technology.

Gene editing is revolutionizing medicine, and Dr. Matthew Porteus, Professor of Pediatrics at Stanford University School of Medicine, is at the forefront of this transformation. Join us for a conversation with Dr. Porteus as he shares his insights on CRISPR technology and its potential to personalize therapies for rare genetic conditions, including sickle cell disease. Discover how this groundbreaking tool not only identifies the root causes of diseases but also paves the way for innovative treatments. As we discuss the challenges of translating gene editing into clinical practice, Dr. Porteus will highlight the ethical considerations and access issues that shape the future of healthcare. Don't miss this opportunity to explore the promise of CRISPR and its impact on the lives of patients.