January 03, 2018

AMP004 - Ageing and Epigenetics

30 minutes

The ageing population and challenges that arise from ageing are one of the great scientific challenges of this time. In the fourth Episode of the Epigenetics Podcast from Active Motif, our host Dr. Stefan Dillinger talks with Dr. Peter Tessarz from the Max Planck Institute for Biology of Ageing about his contributions to the field of ageing and also, which epigenetic factors play a role in this process.

References for this episode

Tessarz Lab: https://www.age.mpg.de/science/research-labs/tessarz/

Hayflick, Moorhead. 1961. The serial cultivation of human diploid cell strains. Exp Cell Res. Dec;25:585-621.

Donna Lowe, Steve Horvath and Kenneth Raj. 2016. Epigenetic clock analyses of cellular senescence and ageing. Oncotarget. 2016; 7:8524-8531. https://doi.org/10.18632/oncotarget.7383

Peter Tessarz, Helena Santos-Rosa, … Tony Kouzarides. 2014. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature. 2014 Jan 23; 505, 564–568. doi:10.1038/nature12819

Peter Tessarz, Tony Kouzarides. 2014. Histone core modifications regulating nucleosome structure and dynamics. Nature Reviews Molecular Cell Biology. 2014 Oct 15: 15, 703–708. doi:10.1038/nrm3890

Payel Sen, Parisha P. Shah, Rafaella Nativio, & Shelley L. Berger. 2016. Epigenetic Mechanisms of Longevity and Aging. Cell. 2016 Aug 11: 166,4,822-839. DOI: http://dx.doi.org/10.1016/j.cell.2016.07.050

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