OpenFold, an open-source, collaborative initiative founded in 2022 to address the challenges of protein structure prediction and design using artificial intelligence, emerged as a response to the restricted commercial access to DeepMind’s AlphaFold platform. Leveraging public datasets and using a pre-competitive consortium model, OpenFold seeks to democratize cutting-edge protein engineering tools for both industry and academia. We spoke to ​Brian Weitzner, director of computational and structural biology at Outpace Bio and co-founder of OpenFold, about the creation of the collaborative effort, how its open licensing model ensures broad accessibility, and how it stacks up against AlphaFold.