If you are interested in developing an interprofessional course to teach the concept of big data, this podcast and article are for you. Dr. Margaret Jeanne Calcote discusses the course they developed that introduces students from the schools of nursing, medicine, and pharmacy to the use of big data in health care. Students use the academic medical center’s Patient Cohort Explorer software application to access electronic health record data. Dr. Calcote explains how the competencies nursing students demonstrated in this course align with the new AACN Essentials.