Andy Lee of Vincere Biosciences. "Our innovative pipeline consists of small molecules designed to boost mitophagy, with the potential to become the first-ever medicines capable of slowing or stopping Parkinson's disease and other age-related conditions."

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PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH

RSS: https://www.learningwithlowell.com/feed/podcast/

Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q

Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA

Website: https://www.learningwithlowell.com/

Andy Lee Links

https://vincerebio.com/team

https://www.facebook.com/Neuroinitiative/

https://twitter.com/VincereBio

https://twitter.com/andy_d_lee

Timestamps

00:00 Intro 

00:13 Bio at AI events, and AI at bio events

02:10 AI at Vincere Biosciences

04:25 Developing inhouse vs open source 

05:45 Huggingface / heart of closed systems

06:25 Mark Zuckerberg on Open source ML / AI systems

08:45 OpenAI to ClosedAI / Elon Musk

10:54 Sharing  / not sharing the weights 

12:00 Mark Zuckerberg  / open source benefit 

14:30 What is Huggingface / where he goes 

17:30 ChatGPT, Huggingface, Nvidia GPUs, developing on laptop

19:00 Vincere Biosciences Building on prem or cloud computing

20:50 Security and building your own system 

22:30 Crypto compute translate to AI compute

24:30 Gold Mining

25:15 Vincere Biosciences explained 

27:40 Mice study results  

30:10 Therapeutic index  / Mitochondria / Basil mitophagy 

32:45 Teaser for results / significance of their research / Parkinson's disease

35:00 Healthspan  / longevity 

38:31 Degrading at different rates

39:20 Increasing vs decreasing levels

41:50 Expect of effect on Parkinson's / Michael J. Fox

44:30 Helping everyone

46:20 Shot, pill, often of taking 

46:50 Age of onset of Parkinsons 

48:40 Taking for life

49:55 Standing in the way of clinical trials  / how long until someone can use it

54:50 Sticking with it / Rare disease / orphan disease 

57:55 Michael J. Fox foundation 

01:01:16 Biobanking, data sharing

01:02:11 Michael J. Fox foundation data lake / 2030s

01:04:20 Learning from other failures 

01:06:40 Book recommendations / Creative Act 

01:12:15 Toxic consequence of boosting mitophagy / Salt and pepper fanQ

01:13:55 Fast tracking phase 1 to phase 2 drug / Fan Q

01:19:40 Staying up to date with Vincere Biosciences