Focuses on critical care physiology and monitoring techniques, providing extensive information on the mechanics of mechanical ventilation and its complications, such as intrinsic Positive End-Expiratory Pressure (PEEP) and ventilator-induced lung and diaphragm injury. Chapters address complex topics like pulmonary gas exchange, using methods such as the multiple inert gas elimination technique (MIGET) and the challenges of measuring dead space and shunt, as well as the evaluation of hemodynamics and fluid responsiveness through techniques like pulse pressure variation and passive leg raising. Furthermore, the text explores the impact of conditions like sepsis and acute neurological injury on various organ systems, including the pulmonary endothelium, heart, and kidneys, while discussing the application and limitations of different clinical severity scores and monitoring tools.
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