The COVID-19 outbreak has led communities to close schools, encourage social distancing and other strategies in order to reduce the spread of the virus. The social isolation that results from being at home and lack of connection to friends and other important figures is stressful, particularly if their families are not supportive of their gender identity. LGBTI people have previously been blamed for disasters, both manmade and natural, and there are scattered reports of this happening in the context of the COVID-19 pandemic. In some countries, reports suggest an increase in homophobic and transphobic rhetoric. There are also reports of police using COVID-19 directives to attack and target LGBTI organizations. In at least one country, the State of Emergency has been used to propose a decree that would prevent transgender people from legally changing their gender in identity documents. A few countries have put in place restriction of movement based on sex, with women and men allowed to leave their homes on alternate days, which have put non-binary and trans people at risk of heightened discrimination, as they may get stopped and questioned. LGBTQ+ people may be particularly vulnerable during the COVID-19 pandemic. People living with compromised immune systems, including some persons living with HIV/AIDS, face a greater risk from COVID-19. Homeless persons, a population that includes many LGTBI people, are less able to protect themselves through physical distancing and safe hygiene practices, increasing their exposure to contagion. LGBTI people regularly experience stigma and discrimination while seeking health services, leading to disparities in access, quality and availability of healthcare. Laws that criminalize same-sexmuch relations or that target trans persons due to their gender identity or expression, exacerbate negative health outcomes for LGBTI people, as they may not access healthcare services for fear of arrest or violence. Examples of health care discrimination based on sexual orientation and gender identity/expression have been extensively documented in many countries. This discrimination can elevate the risk for LGBTI people from COVID-19. Given overloaded health systems, treatment of LGBTI people may be interrupted or deprioritized, including HIV treatment and testing, hormonal treatment and gender-affirming treatments for trans people. Decisions about scaling back services should be medically-based and data-driven, and should not reflect a bias against LGBTI people. Due to stay-at-home restrictions, many LGBTI youthsof are confined in hostile environments with unsupportive family members or co-habitants. This can increase their exposure to violence, as well as their anxiety and depression. LGBTI people are more likely to be unemployed and to live in poverty than the general population. Many in the LGBTI community work in the informal sector and lack access to paid sick leave, unemployment compensation, and coverage. Additionally, due to discriminatory paid leave policies that do not cover all genders equally, LGBTI people may not be able to take time off from work to care for family members.