The prevalence of multimedia technology has influenced modern society in many ways. Technological and economic feasibility have enabled the application of multimedia to physical spaces, where media such as audio, visual and interactive content take on spatial significance.(McCollough 2005, pp. 154-165) This has spurred multidisciplinary ventures in architecture that explore the architectonic potential of multimedia. Particularly relevant, are the progressive spatial applications of multimedia evident in multimedia installation artworks and interactive spaces. Through a case study analysis of 25 works of multimedia installation art and interactive spaces, this paper seeks to understand the manner that multimedia influences an architectural space and determine the significance of such influences in an architectural context.