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Five complete responses in advanced pancreatic cancer should make anyone in biotech sit up. We’re joined by Dr Chris Burns, CEO and Managing Director of Amplia Therapeutics, to unpack what the latest mature ACCENT trial data really says about narmafotinib when it’s added to standard chemotherapy with gemcitabine and Abraxane and why “making other drugs work better” is more than a slogan when patients are running out of time.

We talk through the headline numbers, including an 11.1 month median overall survival signal and what “complete response” means in practical clinical terms. Just as important, we dig into tolerability: the combination appears to keep the side effect burden largely in line with chemotherapy alone, which is critical for any add on cancer therapy hoping to move into larger, registration enabling studies. We also explore how the US FDA fast track designation helps shape timelines and strengthens discussions with potential partners watching the pancreatic cancer pipeline closely.

Not every combo is worth forcing, and are transparent about that. We cover the recruitment halt in the AMPLICITY trial pairing narmafotinib with the more aggressive FOLFIRINOX regimen, why the limiting toxicity was linked to the chemotherapy, and how the broader landscape is shifting toward targeted and personalised medicines, including emerging RAS inhibitors. We finish with the commercial foundations, from key patents extending protection to at least 2040 in major markets to the next 12 months of milestones across pancreatic and ovarian cancer.

If you want clear, investor friendly context on pancreatic cancer drug development, clinical trial readouts, FDA pathways, and partnering strategy, hit play. Subscribe, share this with someone following oncology breakthroughs, and leave us a review with the one result you’ll be watching next.

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A junior explorer doesn’t often get the chance to step into prime ground that’s already been stress-tested by a major miner, right in the middle of a proven hard-rock lithium district. That’s why we sat down with Mitch Thomas, CEO of Solis Minerals, to unpack Solis’ strategic acquisition from Rio Tinto in Brazil’s Lithium Valley and what a 93,000 hectare land position can really mean when the targets are already defined and the plan is to drill.

We talk through the story behind the deal, including why this particular concession package is so compelling, how it sits in a region the team knows intimately, and how Solis’ history of building a lithium discovery next door shapes their technical approach today. Mitch explains what makes the early indicators worth chasing, from high lithium soil results to spodumene pseudomorphs, and why Rio Tinto’s extensive groundwork may give Solus a head start as it moves from surface work into scout drilling.

Lithium isn’t the only pillar. We also dig into Solis’ Peru copper portfolio, how the company thinks about copper porphyry exploration alongside lithium, and why operating across two in-demand energy metals can support more consistent market updates. Mitch also shares why Solis moved to an Australian-registered structure, what it means for ASX investors in terms of governance and liquidity, and the milestones to watch as the company targets drilling around mid-2026.

If you follow lithium exploration, Brazil mining projects, ASX resource stocks, or copper growth stories, hit subscribe, share this episode with a mate, and leave us a review so more investors can find the conversation.

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Guinea supplies a huge share of the traded bauxite market and that concentration is forcing buyers and investors to rethink supply security. We sit down with Ryan De Franck, Managing Director of VBX Limited, to unpack why the Wuudagu Bauxite Project in Western Australia’s North Kimberley could stand out in the global bauxite landscape through a simple idea: pair high-grade, low-silica bauxite with logistics that are short, efficient, and built around real customer needs. 

We talk through what makes Wuudagu strategically significant, from its proximity to the coast and protected sea conditions for transshipment, to the shipping advantage of being closer to key end-user regions such as China, India, and the Middle East. Ryan also explains the impact of VBX’s 108% lift in Measured and Indicated Mineral Resource to 131.9 million tonnes, and how that larger, higher-confidence base supports a bigger development case as the Definitive Feasibility Study progresses. 

Metallurgy gets a spotlight too, with recent test work indicating a 23% increase in mass recovery versus prior assumptions, and what that can mean for operating costs, profit margins, and payback timing if it carries through at scale. We finish with the execution roadmap: the DFS timeline toward mid-2026, a pathway to first production in 2027, and the near-term milestones that matter most, including traditional owner agreements, approvals, and definitive off-take and funding work with strategic partners. 

If you follow ASX mining, bauxite projects, aluminium supply chains, or energy transition materials, this is a sharp update you’ll want in your queue. Subscribe to ASX Briefs, share this episode with a mate watching the sector, and leave a review telling us which milestone you think will be the biggest value driver.

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A kid can’t learn well if the world sounds muffled, painful, or simply out of reach. We’re joined by Dr James Fielding, Managing Director and CEO of Audeara Limited, to talk through a pivotal stretch for this ASX-listed hearing health technology and audio technology company, following strong Q3 FY26 results and a growing global footprint.

We start with what Audeara actually builds: hearing health tech solutions sold as Audeara-branded hardware, plus the AUA Technology platform that can power other brands. James then explains the significance of an exclusive agreement with ShokzHear, the global leader in bone conduction listening devices. The goal is practical and urgent: create an optimised listening option for children dealing with chronic ear infections, particularly in regional and remote communities where in-ear devices can be uncomfortable or unusable. We also discuss just how widespread classroom listening issues can be and what better audio access could mean for learning outcomes.

From there we dig into the numbers investors care about, including back-to-back positive net operating cash flow and accelerating Australian wholesale revenue, supported by closer partner execution with audiology groups such as Amplifon. We finish with Audeara’s Auracast™ momentum, the Clinico partnership in Taiwan, and the BT-03 Audio Broadcaster rollout into environments like universities, hospitals, government buildings, and even sports bars where people can choose exactly what they want to hear.

If you’re tracking ASX small caps, medtech commercialisation, Auracast, bone conduction, or accessible audio, hit subscribe, share this with a mate, and leave a review to help more people find the show.

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Electrification gets most of the headlines, but what happens when an industry needs constant high-temperature heat and the equipment is built for gas? That’s where biomethane and renewable gas infrastructure start to look less like a niche and more like a missing piece of Australia’s decarbonisation plan.

We’re joined by Joe Oliver, Managing Director of Delorean Corporation Limited, to explain how Delorean turns organic waste into renewable energy and why the company is shifting from being known for engineering into becoming a build-own-operate bioenergy infrastructure owner. Joe walks us through the NSW1 Horsley Park final investment decision, including the $30.5 million in non-dilutive grant funding, the 25-year lease and gas offtake agreement with Brickworks, and why the integrated behind-the-meter model can deliver de-risked, infrastructure-style contracted cash flow.

We also dig into the real-world “hard-to-abate” problem for sectors like brick and glass manufacturing and why biomethane is a practical substitute for natural gas that can work with existing infrastructure. With green gas demand rising fast due to corporate targets and regulatory pressure, Joe outlines the current supply-demand gap in Australia and what corporate and technical catalysts to watch over the next 12 months, from financial close through to construction milestones, first gas and first revenue, alongside progress on SA1 and the broader project pipeline.

If you found this useful, subscribe to ASX Briefs, share this episode with a colleague following renewable gas and bioenergy, and leave us a review. What’s the biggest barrier you see to scaling biomethane in Australia?

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A copper story can sound simple until you ask the hard questions: can it be built, can it be funded without brutal dilution, and is there genuine upside left to find? We’re joined by Ivan Fairhall, Managing Director of Pivotal Metals Limited, to walk through how the company is tackling those questions with a dual-track strategy in Quebec, one of the world’s most supportive mining jurisdictions.

We start with the structural edge Quebec offers critical minerals explorers and developers: strong infrastructure, an experienced mining services ecosystem, and access to abundant low-cost hydro power that’s both green and commercially meaningful. Ivan also explains how flow-through shares can help fund exploration more efficiently, a concept many ASX investors haven’t encountered, and why these real-world advantages can change the risk profile of a junior company.

From there we get specific on the Hordern Lake Copper Project, including the existing 37Mt resource at about 1.1% copper equivalent, the appeal of shallow open-pittable mineralisation, and why metallurgy sits at the centre of any credible development plan. We then shift to the Belleterre Project, where Pivotal is drilling for the first time on a district-scale land package with historic high grades nearby and large areas that have barely been tested. Ivan breaks down the targeting approach using modern EM and other geophysics to hunt for new massive sulphide systems, plus what to expect from assay timing and ongoing fieldwork.

If you’re comparing ASX copper stocks, looking for Quebec mining exposure, or trying to understand what separates a “good resource” from a real development opportunity, this conversation gives you a clear framework. Subscribe, share the episode with a mate who follows copper, and leave a review telling us what topic you want us to tackle next.

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Paying rent should be simple, but for millions of Australians it is anything but. Bonds can demand weeks of rent upfront, payment options are often rigid, and renters are left stitching together workarounds just to secure a home and stay on top of weekly costs. We sit down with Jan Ferreira, CEO of Rent.com.au Limited, to unpack how a renter-focused fintech platform can reduce that friction and build a more sustainable business at the same time.

Jan walks us through Rent.com.au’s shift from a rental search portal into a full-service renter platform, anchored by two flagship products. RentBond® is built to bridge the bond gap when renters need to stump up funds before they have even moved out of their current place, including a 21-day repayment window that can be fee-free. RentPay tackles the ongoing grind of rent payments by letting renters choose how and when they pay, across methods like bank transfer, direct debit, credit card, PayPal, and Alipay, while still delivering rent to agents in the way and timing they prefer.

We also dig into the size of the opportunity, with tens of billions in annual rent flows and rents rising sharply, and what that means for product adoption, partnerships, and repeat usage. Jan explains how expanded lending capacity and bringing loans in-house can lift revenue and profit, why recurring revenue changes predictability, and the milestones the team is targeting on the path to positive group EBITDA and cash flow before the end of 2026.

If you care about the future of renting in Australia, fintech in the property ecosystem, or how ASX-listed platforms grow recurring revenue, listen now. Subscribe, share this with a mate who rents, and leave a review, what feature would make renting less stressful for you?

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Heavy rare earths sit at the centre of magnets, electrification, and the modern supply chain, but getting to a product customers will actually buy is the hard part. We’re joined again by Dr Mark Cooksey, Managing Director and CEO of ABx Group Limited, to hear what’s changed since our last chat and why ABx believes its Tasmanian Deep Leads project is moving into a more serious development phase.

We break down ABx’s second high purity mixed rare earth carbonate (MREC) sample and why it stands out: a higher proportion of heavy rare earths and even lower aluminium and iron impurities. Mark explains what MREC is used for, how separation plants think about feed quality, and why customer validation ultimately decides what “good” looks like. We also dig into processing choices for ionic clay rare earths, including what column leaching can tell you about heap leaching potential versus stirred tank leaching, and how that flexibility can shape capital cost, operating strategy, and approvals.

The conversation widens to the bigger Australian critical minerals ecosystem, including ABx’s involvement in the $240m Critical Metals for Critical Industries CRC and the push to accelerate practical R&D that supports real project decisions. We cover the Ucore Rare Metals MOU as a reminder that rare earths are a specification driven market, then switch gears to ABx’s ALCORE technology and the continuous pilot plant being built at Bell Bay to make industrial fluorine chemicals from aluminium smelter byproducts. We close with bauxite updates across Queensland, New South Wales, and Tasmania, and ABx’s priorities through 2026: engineering design, environmental approvals, customer deals, exploration upside, and getting the pilot plant running.

If you found this useful, subscribe to ASX Briefs, share the episode with a mate tracking critical minerals, and leave a review telling us what topic you want next.

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Titanium sits inside some of the most important machines on the planet, yet supply chains are tightening and governments are treating critical minerals like strategy, not just commodities. That’s why we wanted to talk with Tom Langley, CEO of Fortuna Metals Limited, about what the company is uncovering in Malawi, an emerging rutile and graphite province that sits right beside Sovereign Metals’ world-class Kasiya deposit. 

We walk through Fortuna’s Mkanda discovery and what the numbers are hinting at so far, including high-grade rutile at surface and expanding core areas that point to serious scale. Tom explains the logic behind their rapid 0–2 metre sampling strategy, how it helps prioritise drill targets, and why confirming mineralisation at depth is the next value-defining step. We also dig into the deposit style, the role of weathering in concentrating heavy minerals, and why Malawi’s preserved profile can be such a powerful ingredient for rutile projects. 

From there, we zoom out to the bigger picture: why rutile is the highest-grade natural titanium feedstock, where titanium demand shows up in aerospace and defence, and how graphite credits could materially improve project economics. We touch on the market validation coming from next door at Kasiya, including strategic partners, funding interest and offtake agreements, then finish with what investors can watch for through 2026, from drilling programs and an exploration target to a maiden resource and metallurgical testwork. 

If you care about ASX resources, rutile, graphite, titanium supply chains and critical minerals policy, subscribe, share this with a mate, and leave us a review. What’s the single milestone that would most change your view on Fortuna Metals?

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Ancient rocks may hold a faster, cheaper path to low‑carbon energy. We sit down with Dr Krista Davies, Managing Director of Prominence Energy, to unpack how the Gawler Craton’s hot granites, iron‑rich rocks, and deep crustal faults create multiple natural hydrogen “play types” across a massive 64,000 km² land position in South Australia. Krista brings three decades in oil and gas and a pioneering PhD in natural hydrogen to explain, in plain terms, why white hydrogen and helium could reshape heavy industry and unlock new export opportunities.

We walk through the exploration strategy from the ground up. First comes low‑impact soil gas and water bore sampling to detect subtle seepage signatures of hydrogen and helium, providing cost‑effective field validation across broad terrain. Then we integrate those anomalies with structural models to pick the smartest seismic lines, image reservoir and seal configurations, and rank traps before drilling. It’s a disciplined, geology‑led approach that turns a district‑scale thesis into drill‑ready targets while preserving capital and minimising surface disturbance.

Beyond the rocks, we map the market. Hydrogen demand today is big but emissions‑heavy; natural hydrogen offers a discovery‑and‑produce pathway that could lower costs and accelerate adoption for green steel, heavy transport, and industrial heat. Proximity to the Spencer Gulf, Whyalla’s industrial hub, and mining centres near Olympic Dam strengthens the case for local offtake and future export. We also dig into helium’s rising strategic value for MRI, semiconductors, and data centre cooling—an opportunity made sharper since Australia became a net helium importer. If exploration confirms accumulations of both gases, helium can enhance project economics and resilience.

We close with a clear 2026 roadmap: complete the geochemical survey on PEL 803, integrate insights to focus seismic in the second half, then advance a risk‑ranked portfolio toward drilling next year. If you care about energy transition, critical minerals, and practical paths to decarbonisation, this is a grounded, data‑driven look at what could be Australia’s next energy chapter. Follow the show, share it with a friend who follows ASX explorers, and leave a quick review to help others find these conversations.