Audiommunity

I swear, we know how to count; this episode was originally recorded back in January, but Camilla's audio file was weirdly corrupted. And in this attempt, Chadene's computer exploded, but we soldiered on without her.

In this episode, we're discussing Camilla's PhD paper, in which bone-forming cells promote tumors in the lung by activating specialized neutrophils. Yeah, it doesn't make any sense to me either, but it's beautiful work.

The Paper: Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Blog post (suitable for non-immunologists)

Kevin's beers: Whirlpool (from Night Shift) and Conehead (from Zero Gravity)

Camilla's beer: A Year with Dr. Nandu

Figure 2 B from https://doi.org/10.1073/pnas.1716937115

In this episode, Chadene, Kate and Kevin discuss Kate's recently published paper about how STING, once thought to be involved only in defense against DNA viruses, actually slows RNA virus replication as well. Also, Chadene throws herself under the bus, and Kevin manages to only talk for about 20% of the time. 

• The paper: STING-dependent translation inhibition restricts RNA virus replication
• Kate's... drink? - TW Pitchers Radler
•  Kevin's beer: Mayflower Brewing Oatmeal Stout

Graphical abstract from the paper. Guys, Matt and I don't charge that much to help with figure design...

In this episode, we're talking about Salmonella, and the peculiar way in which it tries to keep you eating to keep you alive. Who knew pathogens could be so kind?

Also, Chadene struggles to introduce the podcast, and Kate decides to Kevin 4 years later that we're misspelling the name of the podcast. Too late now!

The Paper: Pathogen-mediated inhibition of anorexia promotes host survival and transmission
Kate's Shandy (Sorry, I refuse to put a link to Rolling Rock)
Resorb - (eg Scandinavian magic)

Neutrophil grabbing Staph. From Wikipedia

No, your eyes aren't deceiving you, and yes, we know how to count... Episode 29 is still in limbo as Camilla valiantly attempts to re-record just her portion. 

In this episode, Kevin and Camilla discuss Salmonella virulence, and how different strains alter the immunogenicity of pathogens. Oh, and Kate's here too... KATE'S BACK!! WOO!! Dr. Franz has a new job, but is just as snarky and ill-prepared as ever. Plus she refuses to drink on the job.

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EDIT: Sorry if this showed up in your feed late - there was a mistake in formatting :-(

The Paper: Strains of bacterial species induce a greatly varied acute adaptive immune response: the contribution of the accessory genome
Short Path Distillery
Organ Preservation Alliance (where Kate works now)

Blame Kevin for the delay on this one - it's hard to edit podcasts in Hong Kong.

Today (well, three weeks ago), Matt and Kevin talked about epitope spreading in Lupus, and a ton of crazy mouse models that allowed researchers to dissect the way a single auto-reactive B-cell clone can spread the disease party to its neighbors. 

Also in this episode - Kevin complains about politicians' views on global warming (I can't link the map because of the government shutdown), and Matt totally doesn't have any conflicts of interest on this paper...

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- The Paper - Clonal evolution of autoreactive germinal centers (it's behind a paywall, and we definitely won't send you the PDF if you e-mail us at [email protected]... definitely not)
- Blah, Blah, Blah IPA from 21st Amendment
- What Matt was drinking. Not a mistake.

In this episode, we're talking cure for the common cold... or at least, a vaccine for it. Also, Kevin and Matt read the wrong paper, Chadene corrects Kevin's pronunciation of her name (again!) and we give a big round of applause for Dr. Kate Franz (though she's still too busy for us).

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The Paper: A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
Guardian article about the effort to develop a rhinovirus vaccine
Chadene's Blog - The SciMinded Idealist (and her post about episode 26)
Kevin's Beer - Left Hand Milk Stout

In this episode, we're talking cancer, checkpoint blockade and poop - what's not to love? Also, Camilla is the only one drinking, Matt thinks the study needs more mice, and it took Kevin an extra 2 hours to edit this episode to remove all (he hopes) of his sniffles.

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A paper-heavy links section this time:

• The paper: Gut microbiome modulates response to anti–PD-1  immunotherapy in melanoma patients
• Background paper (more mice, so Matt likes this one better)
• Camilla's recently published paper about bone cells, neutrophils, and cancer

OMG, Audiommunity is back! With a... vengeance? That doesn't make any sense. But we're back!

We've got a couple of new hosts - Please give a warm welcome to Chadene Tremaglio and Camilla Engblom! Kate is still holed up in a cave (lab) trying to wrap up her PhD. But she'll soon return... we hope...

Audiommunity is now accepting donations via Patreon. The way it works is that you set up a pledge amount that we'll get each time we release an episode (up to a maximum you set). We'll keep doing this for free, but if you value the podcast, please consider tossing a buck or two our way!

The "original" alcoholic ginger beer
Thomas Benjamin (Chadene lied... there's no wikipedia page!)
Filtered Fecal Transplant Paper
Evo Devo (Desposito Cover) - Also check out this guy's patreon page, this stuff is great!
 

Path of Devil Facial Tumor Disease. Figure 1 from doi:10.1038/ncomms12684

Audiommunity loves Tasmanian devils, so we bite the shit out of them... In this episode, we're talking about a contagious tumor that couldn't happen to a nicer species. No seriously, it really couldn't. Tasmanian devils bite each other on the face to say hello. WTF devils?

And we answer audience e-mail that's been in the inbox for months! I know, I know... we're going to record more frequently going forward - honest!

Links

Paper: Rapid evolutionary response to a transmissible cancer in Tasmanian devils

Gross pictures of devil tumor facial disease

This week - Evidence that viruses drive the evolution of their hosts - who would have guessed? Matt struggles to remember how evolution works, and Kate and Kevin yell past each other about open peer review.

We initially recorded this episode a month ago, but Kevin messed up his audio settings and his recording was unusable. So sorry as always for the delay, but we hope you enjoy!

Links

Paper (open access): Viruses are a dominant driver of protein adaptation in mammals
SIT'N Listen - A Podcast from Science in the News
Classic McDonald-Kreitman Test (wikipedia)
Kevin's many posts and podcasts about science publication

Kate's Beer (between Bud Light Lime and Mayflower Porter): Pacifico
Kevin's beer (once again): Grey Lady