Welcome to This Week in Ophthalmology. This week we're covering 10 notable papers spanning glaucoma risk stratification, retinal imaging and pharmacotherapy, and pediatric and anterior segment practice — including two randomized trials that may change what you offer in clinic tomorrow. Let's dive in.

This week's papers:

1. Standardized Lacrimal Sac Massage vs Probing for Congenital Nasolacrimal Duct Obstruction in Infants: A Noninferiority Randomized Trial — JAMA Ophthalmology 2026
2. Time-Varying Effects of Valacyclovir Prophylaxis in the Zoster Eye Disease Study: A Post Hoc Exploratory Analysis of a Randomized Clinical Trial — JAMA Ophthalmology 2026
3. Efficacy and Safety of Dual-Sided Composite Defocus Spectacles for Myopia Control in Children: A 1-Year Randomized, Double-Masked, Controlled Trial — Ophthalmology 2026
4. Faricimab for Polypoidal Choroidal Vasculopathy: 48-Week Results from the Phase 3b/4 SALWEEN Trial — Ophthalmology Retina 2026
5. Intraocular Lens-Associated Uveitis-Glaucoma-Hyphema Syndrome — American Journal of Ophthalmology 2026
6. Long-term Outcomes of Selective Laser Trabeculoplasty on Intraocular Pressure Control and Visual Field Progression — American Journal of Ophthalmology 2026
7. IOP Stress Testing Identifies Glaucoma Eyes at Risk of Fast Progression Despite Controlled Office Pressure — American Journal of Ophthalmology 2026
8. Assessment of Ellipsoid Zone Integrity and Other Quantitative OCT Biomarkers for Intermediate AMD Progression to Atrophy — Ophthalmology 2026
9. Refractive Predictability of Third-Generation and Modern IOL Power Calculation Formulas in Yamane Intrascleral Fixation — American Journal of Ophthalmology 2026
10. Incidence and Risk Factors for Progression of Pachychoroid Subtype — JAMA Ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we're covering 10 notable papers spanning screening access and equity, artificial intelligence and standardized language in clinical practice, imaging biomarkers and drug trials in retina, and refinements in cataract and corneal surgery. Let's dive in.

This week's papers:

1. Standardization of Retinal Vasculitis Terminology With Consensus Definitions From a Delphi Panel — JAMA Ophthalmology 2026
2. No-History IOL Power Calculation After Myopic Laser Vision Correction: A Multicenter Retrospective Database Study of 14 Formulas With and Without Posterior Corneal Curvature — American Journal of Ophthalmology 2026
3. Preloaded Descemet membrane endothelial keratoplasty: A systematic and descriptive review of global experimental and clinical outcomes — Survey of Ophthalmology 2026
4. Pharmacologic Interventions for the Prevention and Treatment of Proliferative Vitreoretinopathy: A Systematic Review and Meta-Analysis — Ophthalmology Retina 2026
5. Image-based AI for Automated Diagnosis and Clinical Activity Grading in Thyroid Eye Disease: A Systematic Review and Meta-analysis — Ophthalmology 2026
6. Cancer Type-Specific Risks of Retinal Vascular Occlusion: A Nationwide Population-Based Study — Ophthalmology Retina 2026
7. Macular atrophy in neovascular age-related macular degeneration: Prevalence, risk factors, imaging features, and clinical implications — Survey of Ophthalmology 2026
8. Directional Association Between Perilesional Fundus Autofluorescence and Geographic Atrophy Border Expansion — Investigative Ophthalmology and Visual Science 2026
9. Integrating opportunistic ocular diseases screening into general health examination in Chinese: a multicentre study — British Journal of Ophthalmology 2026
10. Neighborhood Socioeconomic Deprivation and Adherence to Diabetic Retinopathy Screening Guidelines — American Journal of Ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we're covering 10 notable papers spanning vitreoretinal surgery and its downstream complications, medical and laser management of macular disease, and access and quality issues in corneal care. Let's dive in.

This week's papers:

1. Factors Associated with Endothelial Cell Density at One Year in the Diabetes Endothelial Keratoplasty Study. — Ophthalmology 2026
2. Dropless Pars Plana Vitrectomy Using Intravitreal Decanted Triamcinolone and Moxifloxacin: Safety and Efficacy. — Retina (Philadelphia, Pa.) 2026
3. Association between Treated Retinal Breaks and Epiretinal Membrane Development. — Ophthalmology Retina 2026
4. Risk of Pseudophakic Cystoid Macular Edema in Eyes With Previous Pars Plana Vitrectomy. — JAMA Ophthalmology 2026
5. Sustained High-Intensity Lipophilic Statin Use and Risk of Age-Related Macular Degeneration: A Target Trial Emulation. — Ophthalmology Retina 2026
6. Nd:YAG Laser Vitreolysis For Primary Symptomatic Vitreous Floaters: A Systematic Review and Meta-analysis. — Ophthalmology Retina 2026
7. Efficacy and safety of subthreshold laser in patients with acute central serous chorioretinopathy: a systematic review and meta-analysis. — Retina (Philadelphia, Pa.) 2026
8. High Incidence of Contralateral Retinal Detachment in Patients with Giant Retinal Tears: A Retrospective Cohort Study. — Retina (Philadelphia, Pa.) 2026
9. Evaluating the Efficacy and Safety of Topical Difluprednate in Patients with Chronic Central Serous Chorioretinopathy. — Retina (Philadelphia, Pa.) 2026
10. Challenges to the Access and Utilization of Corneal Cross-Linking in Keratoconus Patients in the United States. — American Journal of Ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we're covering 10 notable papers spanning artificial intelligence and gene therapy, retinal vascular and macular disorders, surgical innovations in the anterior segment, and advanced diagnostic imaging. Let's dive in.

This week's papers:

1. AI-based clinician decision support system for diagnosis of inherited retinal diseases: a multicenter, randomized trial. — Nature Medicine 2026
2. Interim Results From a Multicenter Observational Safety Study of Patients Treated With Voretigene Neparvovec-rzyl in the United States. — Ophthalmology 2026
3. Anti-VEGF versus Laser Photocoagulation Surgery for Primary Treatment of Retinopathy of Prematurity: Neurodevelopmental Outcomes: A Report by the American Academy of Ophthalmology. — Ophthalmology 2026
4. Comparison of Retinal Nonperfusion in Diabetic Macular Edema Treated with Brolucizumab Versus Aflibercept: A KINGFISHER Trial Analysis. — American Journal of Ophthalmology 2026
5. Faricimab for High-Need Aflibercept 2 mg Treated Neovascular Age-Related Macular Degeneration. — Ophthalmology Retina 2026
6. Cultured Human Corneal Endothelial Cell Injection Therapy in Phakic Eyes with Bullous Keratopathy. — American Journal of Ophthalmology 2026
7. Combined Limbal Epithelial and Stromal Cell Transplant for Aniridia-Related Keratopathy: A Nonrandomized Clinical Trial. — JAMA Ophthalmology 2026
8. Eye-Preserving Therapies for Early cT3c Retinoblastoma. — Ophthalmology 2026
9. Non-exudative fluid in age-related macular degeneration: Imaging, pathophysiology, and clinical implications. — Survey of Ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we're covering ten notable papers spanning advanced retinal imaging and therapeutics, diabetic retinopathy management and access disparities, and the systemic and demographic factors influencing ocular disease. Let's dive in.

This week's papers:

1. Global Axial Length Centile Charts. — JAMA ophthalmology 2026
2. Microinvasive pars plana vitrectomy versus panretinal photocoagulation for severe non-proliferative diabetic retinopathy: a randomised controlled trial. — The British journal of ophthalmology 2026
3. Factors Associated With Progression to Primary Angle Closure: A Post Hoc Analysis of the ANA-LIS Trial. — JAMA ophthalmology 2026
4. One-Year Results of Geographic Atrophy Patients with Pre-Existing nAMD treated with both anti-VEGF therapy and pegcetacoplan. — Retina (Philadelphia, Pa.) 2026
5. Prognostic value of subretinal hyperreflective material as an imaging biomarker in the treatment of neovascular age-related macular degeneration: A systematic review. — Survey of ophthalmology 2026
6. Hyperreflective Abnormal Areas in the Middle Retinal Layers on En Face OCT for Diagnostic Discrimination in Diabetic Eyes. — American journal of ophthalmology 2026
7. Geographic Distribution of Access to Diabetic Retinopathy Care in the United States: An American Academy of Ophthalmology IRIS Registry (Intelligent Research in Sight) Analysis. — Ophthalmology 2026
8. Risk of Incident Dry Eye Disease Among Patients with Chronic Pain Conditions. — American journal of ophthalmology 2026
9. Acanthamoeba keratitis: Insights into diagnostic challenges and treatment advances. — Survey of ophthalmology 2026
10. Ophthalmic Disease Burden in Adults with Autism Spectrum Disorder. — American journal of ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we are covering ten notable papers spanning three major areas: optimizing glaucoma monitoring and preventative therapies, refining safety and outcomes in retinal disease management, and understanding patient-centered trajectories in ocular surface and systemic inflammatory conditions. Let's dive in.

This week's papers:

1. Nicotinamide Supplementation and Primary Open-Angle Glaucoma in Patients With Ocular Hypertension. — JAMA ophthalmology 2026
2. Value of 10-2 Visual Field Testing for Detecting Progression in Patients with Glaucoma. — Ophthalmology 2026
3. Safe use of fluorinated gases in vitreoretinal surgery: learning from patient safety incidents with expert panel recommendations from the British and Eire Association of Vitreoretinal Surgeons (BEAVRS). — The British journal of ophthalmology 2026
4. Comparative Five-Year Risks of Systemic Complications with Biologic versus Conventional Therapy in Non-infectious Uveitis. — Ophthalmology 2026
5. Post-approval outcomes of voretigene neparvovec (Luxturna®) retinal gene therapy: A systematic review and meta-analysis. — Survey of ophthalmology 2026
6. Risk and Predictors of Fellow-Eye Involvement Following Unilateral Retinal Artery Occlusion. — Ophthalmology. Retina 2026
7. Ocular Symptoms After Refractive Surgery. — JAMA ophthalmology 2026
8. Fast progressors in Asian normal-tension glaucoma: 10 years and beyond in a longitudinal cohort. — The British journal of ophthalmology 2026
9. Autograft versus Allograft in Indirect Corneal Neurotization: A Systematic Review. — American journal of ophthalmology 2026
10. Detection of Hyporeflective Core Drusen and the Onset of Large Choroidal Hypertransmission Defects in Intermediate AMD. — American journal of ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we are covering ten notable papers spanning diagnostic innovations in glaucoma, prognostic tools in vitreoretinal surgery, and global patterns in inflammatory eye disease. Let us dive in.

This week's papers:

1. Diagnostic Performance of Prespecified OCT Rules for Glaucomatous Optic Neuropathy in Nonpathologic Myopia. — JAMA Ophthalmology 2026
2. Effect of key baseline disease characteristics on aflibercept 8 mg dosing interval extension: A post hoc 96-week analysis of PULSAR. — Ophthalmology. Retina 2026
3. Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures. — Investigative ophthalmology & visual science 2026
4. Trends in pediatric uveitis: A systematic review and meta-epidemiological investigation of geographic, economic, and climate factors. — Survey of ophthalmology 2026
5. Identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning. — The British journal of ophthalmology 2026
6. Visual Recovery After Surgery in Epiretinal Membrane Eyes with Retinal Nerve Fiber Layer Schisis and Internal Limiting Membrane Tear. — Ophthalmology. Retina 2026
7. Masquerading disease of macular telangiectasia type 2 - MacTel Project Report No 11. — Ophthalmology. Retina 2026
8. Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis. — The British journal of ophthalmology 2026
9. Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery. — Investigative ophthalmology & visual science 2026
10. Posterior Segment Pressurization With Intravitreal Balanced Salt Solution to Stabilize Anterior Chamber Gas During Endothelial Keratoplasty. — Cornea 2026

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Welcome to This Week in Ophthalmology. This week we're covering 9 notable papers spanning key advancements in retinal disease management, corneal and ocular surface health, and new predictive models for optic nerve pathology. Let's dive in.

This week's papers:

1. Cryo-electron microscopy structures of human cone visual pigments. — Science 2026
2. Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction: Follow-Up of a Randomized Clinical Trial. — JAMA Ophthalmology 2026
3. Neuroretinal Layer Thinning on OCT Imaging and Hemoglobin A1c in Youth With Type 1 Diabetes. — JAMA Ophthalmology 2026
4. Corneal Epithelial Alterations Associated With CDK4/6 Inhibitor Therapy in Hormone Receptor-Positive Breast Cancer. — American Journal of Ophthalmology 2026
5. Estimation of high myopia-associated optic neuropathies: the Two-Continent Eye Study. — The British Journal of Ophthalmology 2026
6. Dopamine-Enhancing Therapies and Risk of Neovascular AMD Conversion: A Target Trial Emulation. — American Journal of Ophthalmology 2026
7. Association between statin use and dry eye disease: A systematic review and meta-analysis. — American Journal of Ophthalmology 2026
8. Therapeutic response to anti-VEGF retreatment among eyes with stabilized vision after being lost to follow-up in diabetic macular edema: A nationwide, registry-based cohort study. — American Journal of Ophthalmology 2026
9. Cataract Surgery and the Risk of Conversion from Dry to Neovascular Age-related Macular Degeneration in the IRIS Registry. — Ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we're covering 9 notable papers spanning advances in retina, new evidence in cornea and anterior segment care, and insights into myopia and ophthalmic research methods. Let's dive in.

This week's papers:

1. Stereotactic radiotherapy for neovascular age related macular degeneration: year 3 and 4 extended follow up results of a randomised, double masked, sham controlled, device trial (STAR). — BMJ (Clinical research ed.) 2026
2. Antifungal Therapy for Fusarium Keratitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. — Cornea 2026
3. OCT-Based Quantitative Comparison of Full-Thickness Healing of Corneal Incisions in Cataract Surgery Between Diabetic and Nondiabetic Patients. — Cornea 2026
4. Real-World Insights on Switching Aflibercept Dosage for Enhanced Outcomes in Retinal Vein Occlusion (RISE-RVO): visual, anatomical and durability outcomes. — The British journal of ophthalmology 2026
5. Glaucoma in UK Biobank: A Comparison of Diagnostic- Versus Treatment-based Definitions. — Ophthalmology 2026
6. SEARCHING FOR NEW GENES THAT CAUSE USHER SYNDROME. — American journal of ophthalmology 2026
7. PROSTACYCLIN ANALOGS AND DIABETIC RETINOPATHY OUTCOMES IN PATIENTS WITH PULMONARY HYPERTENSION : A Cohort Analysis. — Retina (Philadelphia, Pa.) 2026
8. Can switching between different types of myopia control spectacles enhance effectiveness? Findings from a real-world study. — The British journal of ophthalmology 2026
9. Descemet Stripping Only in Fuchs Endothelial Corneal Dystrophy: Results of a Randomized Clinical Trial of Topical Ripasudil and Directions for Future Innovation. — American journal of ophthalmology 2026

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Welcome to This Week in Ophthalmology. This week we're covering 9 notable papers spanning new therapeutic approaches in retina, refinements in managing uveitis, and how new technology is changing risk stratification and diagnosis. Let's dive in.

This week's papers:

1. Subretinal Gene Therapy for X-Linked Retinoschisis. — The New England journal of medicine 2026
2. Polygenic risk impacts lifetime risk and prognosis of glaucoma. — Ophthalmology 2026
3. Quantitative Swept-Source Optical Coherence Tomography Angiography Indicators of Neurovascular Dysfunction in Alzheimer Disease. — JAMA ophthalmology 2026
4. 12-month outcomes of photobiomodulation in dry age-related macular degeneration: a prospective multicentre randomised double-masked controlled clinical trial. — The British journal of ophthalmology 2026
5. Anti-Adalimumab Antibodies in Patients with Inflammatory Ocular Diseases: Incidence and Clinical Outcomes. — American journal of ophthalmology 2026
6. Diabetic Retinopathy Outcomes Among Unhoused Individuals: A Big Data Analysis. — Retina (Philadelphia, Pa.) 2026
7. Evaluating reasoning in multimodal large language models for ophthalmology: a bilingual benchmark study using clinical vignettes and imaging. — The British journal of ophthalmology 2026
8. Herpesvirus Retinitis by Immune Status: Clinical Phenotypes and Predictors of Retinal Detachment and Severe Visual Impairment. — Ophthalmology. Retina 2026
9. Development of diagnostic criteria for Behçet's uveitis in a Chinese population. — The British journal of ophthalmology 2026

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