Authentic Biochemistry

By Dr Daniel J. Guerra

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FAQs about Authentic Biochemistry:

How many episodes does Authentic Biochemistry have?

The podcast currently has 1,125 episodes available.

Authentic Biochemistry episodes:

October 14, 2023 BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23
Mol Cell Biol. 2012 Jan;32(1):126-38
Mutat Res. 2013 Jul-Sep;753(1):24-40
Molecular Neurobiology 2022. volume 59, pages 4223–4241

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29min
October 12, 2023 BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.
References
Molecular Neurobiology 2022. volume 59, pages 4223–4241
Hum Genet. 1994 Jan;93(1):67-73
Mol Cell Biol. 2012 Jan;32(1):126-38
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30min
October 12, 2023 BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry
References
The EMBO Journal (2022)41:e109108
Acta Neuropathol. 2007 Sep;114(3):221-9
Acta Neuropathol.2013 Jul; 126(1): 51–57
Brain 2008. Volume 131, Issue 6, Pages 1416–1432
Lovin Spoonful 1968. "She's a Lady" https://youtu.be/xyFdzevDOHg?si=bLl8FZzfE2SffvO4
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30min
October 10, 2023 BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD
References
Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74LR2JY
The EMBO Journal (2022)41:e109108
PLoS ONE 2013. 8(6): e65646. doi:10.1371/journal.pone.0065646
Molecular Neurodegeneration 2022. volume 17,Article number: 73

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30min
October 10, 2023 BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation
References
Mozart, WA. 1791. Clarinet Concerto in A major, K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5
Small GTPases. 2014; 5: e28579
Acta Neuropathol. 2023; 145(6): 749–772
J Immunol. 2000 May 15;164(10):4991-5

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30min
October 08, 2023 BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.
References
Mol Biol Cell. 2001 Sep; 12(9): 2711–2720.
Small GTPases. 2014; 5: e28579.
Cells. 2021 Jul 20;10(7):1831.
J Investig Med. 2023 Feb;71(2):113-123

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30min
October 08, 2023 BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.
References
Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC
Acta Neuropathol. 2023 Jun;145(6):749-772
Signal Transduction and Targeted Therapy 2022. volume 7, Article number: 175
Cardiovascular Research 2007. 74: 526 – 536
J Investig Med. 2023 Feb;71(2):113-123

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30min
October 05, 2023 BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.
References
Neurol Genet. 2018 Jan 18;4(1):e211.
J Immunol (2003) 171 (2): 594–599.
Acta Neuropathol. 2023; 145(6): 749–772.
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30min
October 05, 2023 BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.
References
Neurology. 2020 Jul 7; 95(1): e46–e58
Acta Neuropathol. 2023; 145(6): 749–772.
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30min
October 02, 2023 BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD
References
Curr Opin Pharmacol. 2021 Apr; 57: 107–116

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30min

FAQs about Authentic Biochemistry:

How many episodes does Authentic Biochemistry have?

The podcast currently has 1,125 episodes available.