Background and Aim: There are significant disparities in stroke care and outcomes betweenlow- and middle-income countries compared to high-income countries. Haiti, a lower-middle-incomecountry, suffers from a lack of resources for acute stroke management. This study is the first to reportthe epidemiological profile of the Haitian population presenting with stroke symptoms at the largestacademic hospital in the nation. Methods: This is an observational study conducted over a period of 5 months from April 2021 toAugust 2021 in the Internal Medicine Department of the State University Hospital of Haiti. Therewere 51 included patients who were suspected to have had an acute stroke. A descriptive statisticalanalysis was conducted. A scoping review of the literature was also conducted. Results: Over 50% of included patients were between 19 and 65 years old. The mean age atpresentation was 61 years, and patients were predominantly female (64.7%). The prevalence of severemotor deficits was over 96%. The mean National Institutes of Health Stroke Scale was 12. Only15.7% of patients (8/51) had a computed tomography (CT) scan during their hospitalization. Themedian time to CT scan was 84 h after symptom onset. About 80% of those with complicationstook more than 24 h to arrive at the hospital after the onset of symptoms. Eleven percent of patientshad complications, and the mortality rate was 3.9%. There was a significant association between theModified Rankin Scale and the occurrence of complications (p = 0.016). National Institutes of HealthStroke Scale (NIHSS) score had a significant association with the Glasgow score (F = 6.3; p < 0.001)where an inversely proportional correlation was observed between them (r = −0.7; p < 0.001) and aproportional correlation with the Rankin prediction score and the NIHSS (r = 0.3, p = 0.04). Little isknown about the epidemiology of stroke patients in Haiti, and this limits the ability to develop targetedinterventions to improve outcomes. In our scoping review, only three pertinent studies were identifiedover a 25-year period, this leads to a lack of data in regard to stroke care in Haiti mainly due to theabsence of trained personnel. Conclusion: In our cohort, stroke is mainly affecting female patients. The majority of stroke patientshave moderate to severe motor deficits and took more than 24 h to arrive at the hospital. Urgentassistance is needed to strengthen personnel and infrastructure dedicated to stroke. Neurologicalassessment based on NIHSS and Rankin score should be systematic in stroke evaluation in Haiti. Relevance for Patients: This study is relevant for patients because it emphasizes the challenges ofstroke management in Haiti due to the non-availability of reference drugs, the time to arrive at thehospital to start treatment, as well as the means of diagnosis which are limited, like the CT scan.While stroke prevalence is on the rise in the country, it is the highest in the Caribbean and LatinAmerica region.