Watson has never heard Sherlock Holmes refer to his relations and has come to the conclusion that Holmes is an orphan. But on a summer evening, Holmes surprises the good doctor with the news that he has a brother, Mycroft Holmes, who is a greater reasoning and deducing machine than the famous detective. Sherlock whisks Watson away to the Diogenes Club. Once there, they find that Mycroft is himself in an investigation. A famous Grecian Interpreter has just gone through a horrifying experience and will need both Holmes brothers to discover the fate of the man with the sticking plaster on his face...

With special guests Ben Stockman, Noah Smith, and Nell Curley.

After the read, Jay and Tony discuss whether Moriarty is overrated, Mycroft's place in the canon, and which artist named Vernet is Conan Doyle talking about.

Sherlock Holmes is in a foul mood. His most recent chemical investigation has been brought to a premature end by a broken test tube. Perhaps a stroll through London with Watson will cheer him up? When they return, they will find Dr. Trevelyan nervously waiting for them. The good doctor's resident patient is in a pitiable state. Someone has been sneaking into his rooms. He may even know who it is, but can't bring himself to tell anyone. Holmes had better change his mind quickly before things turn deadly...

After the read, Jay and Tony talk Conan Doyle's self-plagiarism, how this story connects to "The Cardboard Box," and tease an upcoming announcement.

Watson and his wife, Mary, have just sat down for breakfast when a telegram arrives from Sherlock Holmes. Can Watson come with him right away to the Boscombe Valley? A dreadful murder has occurred and the victim's son has been arrested. But Holmes believes the young man's protestations of innocence. He just has to prove them before the boy is convicted...

With special guests Dawn Grobe, Jonathan Kinnersley, Geof Dolman, and Jessica Gelter.

After the read, Baker Street Readers' own Lestrade, Jonathan Kinnersley, joins Jay and Tony in a discussion of Inspector's relationship to Holmes, Poe's Dupin stories, and whether the ending of this story makes sense.

Sherlock Holmes and Dr Watson are sitting on either side of the fire at 221b Baker Street, having a lively discussion. Holmes believes that "life is infinitely stranger than anything which the mind of man could invent," but Watson remains skeptical. As though to prove Holmes right, Miss Mary Sutherland appears at the door. No one knows what has happened to her fiancée and no one seems to care. Holmes has an answer, though it may not be one she can accept...

With special guests Kirby Landers and Sam Murphy.

After the read, Jay and Tony answer listen questions, cast the Muppet's Sherlock Holmes movie, and discuss Conan Doyle's terrible ending to this story.

Between his new practice and a new marriage, Watson has seen very little of his friend, Sherlock Holmes. But his way home tonight leads him to Baker Street, and he is seized with a keen desire to see his friend. But Holmes won't just be visited by Watson tonight, a German nobleman in a mask is on his way as well, with a case that will bring Holmes face to face with the infamous Irene Adler...

With specials guests Anders Burrows and Olivia McNeely.

After the read, Anders joins Jay and Tony in a discussion about Conan Doyle's made up kingdoms, how Irene Adler (and Holmes) has been changed by popular culture, and present another segment of "Unheard Cases."

Watson's wedding approaches, but he can't help but feel depressed. The bleak autumnal weather and his old war wound acting up have made him listless. If only Holmes would return home to open that letter on the table, the one with the huge crest and monogram...

With specials guests Daniel Patterson, Jonathan Kinnersley, Shannon Ward, and Conor Dewey.

Stay tuned after the story to hear Jay and Tony discuss the move to the Latchis, recent Sherlock news, and introduce a new segment, "Holmes and Watson aren't gay! But if they were..."

Jay and Tony discuss moving to the Latchis Theatre and the Readers summer season.

Watson sits at home on a fine morning, newly married and the proud owner of a new medical practice. But truly he wishes he could be on another adventure with his friend, Sherlock Holmes. Luckily, Holmes arrives at his door with just such an adventure. Mr Hall Pycroft has been offered a job that seems too good to be true, and his new employer is too bizarre to be trusted. Holmes, Watson, and Pycroft must confront this man together, little knowing how deep his plan truly goes…

All of Europe rings the name of Sherlock Holmes after his remarkable defeat of Baron Maupertuis, yet the detective finds himself in ill health and bad spirits. Dr Watson prescribes a country holiday at the home of his friend, Colonel Hayter. But their relaxation soon comes to a halt when Inspector Forrester arrives imploring Holmes to take on a burglar case that has turned deadly...

With special guest Anders Burrows.

Inspector Lestrade has a case he feels is very much in Holmes' line. A seemingly innocent matron has received a gruesome packet in the post. Lestrade is convinced it is part of a practical joke, but Holmes knows the truth - a terrible crime has been committed. If only he can find the real victims...

With special guests Jonathan Kinnersley, Shannon Ward, and Jessica Gelter.

After the Read, Jay and Tony discuss Tony's favorite Watson story, their "lovers-not-experts" approach, and other Holmes stories involving extra-marital affairs.