In today's episode we discuss an immune-mediated disease, eosinophilic esophagitis, or EoE. We review the symptoms, risks, and damage this disease can cause. We also get into what happens inside the body during and what's being done in both standard medicine and clinical research to try to end EoE.

References:

[1] Muir, A., & Falk, G. W. (2021). Eosinophilic esophagitis: a review. Jama, 326(13), 1310-1318. https://pmc.ncbi.nlm.nih.gov/articles/PMC9045493/

[2] Nurko, S., & Furuta, G. T. (2006). Eosinophilic esophagitis. GI Motility online. https://www.nature.com/gimo/contents/pt1/full/gimo49.html

[3] Rochman, Y., Kotliar, M., Ben-Baruch Morgenstern, N., Barski, A., Wen, T., & Rothenberg, M. E. (2023). TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis. Science signaling, 16(802). https://pmc.ncbi.nlm.nih.gov/articles/PMC10602003/

[4] Dellon, E. S., Gonsalves, N., Hirano, I., Furuta, G. T., Liacouras, C. A., & Katzka, D. A. (2013). ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). American Journal of Gastroenterology, 108(5), 679-692. https://journals.lww.com/ajg/fulltext/2013/05000/ACG_Clinical_Guideline__Evidenced_Based_Approach.10.aspx?context=FeaturedArticles&collectionId=2

[5] He, R., & Geha, R. S. (2010). Thymic stromal lymphopoietin. Annals of the New York Academy of Sciences, 1183(1), 13-24. https://pmc.ncbi.nlm.nih.gov/articles/PMC2895428/