Guido Maniscalco is a Tampa native and first generation American, the son of Cuban and Italian immigrants. He was born in West Tampa and graduated from Tampa Catholic High School and earned a degree from the University of South Florida.
In 2015, he was first elected to the Tampa City Council. In 2019, he was re-elected and currently serves District 6 (West Tampa, Seminole Heights, Westhore).
As of May 2019, he serves as chair pro-tem of the Tampa City Council, member of the Metropolitan Planning Organization, chairman of the Hillsborough River Board, member of the Tampa Bay Estuary Policy Board, member of the Tampa Theatre Board, and board member at Blanket Tampa Bay.