Base by Base - Music

This release contains only the music track from Base by Base Episode 452.

Song title: Quem Ainda Faz Ninho
Original Base by Base episode: 452: Reduzir a PrP funciona em todas as linhagens [PT]

Article metadata:
Article title: Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
Journal: Nucleic Acids Research
DOI: 10.1093/nar/gkaa616
Reference: Minikel EV, Zhao HT, Le J, O’Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-ura K, Beck M, O’Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints. Nucleic Acids Research. 2020;48(19):10615–10631. doi:10.1093/nar/gkaa616

Lyrics:
Verso 1
Na bancada, madrugada,
tem alguém pra anotar:
não sabe quem tomou nada,
não sabe quem vai melhorar.

Só marca se fez o ninho,
se arrumou o seu lugar,
se no pau que fica girando
ainda deu pra se aguentar.

Pré-refrão
A doença não vem gritando,
não bate na porta, não chama:
vai levando de mansinho
o passo, o peso e a cama.

Refrão
QUEM AINDA FAZ O NINHO
ainda tem o que contar!
QUEM AINDA FAZ O NINHO
não desistiu de ficar!
Pouco já muda o caminho —
anota aí: dá pra segurar!

Verso 2
Cinco jeitos diferentes
da mesma coisa chegar;
foram todos, um por um,
nenhum deles escapar.

E o bicho não aprendeu
o caminho de driblar:
voltaram pra ver de novo
e não teve como passar.

Ponte
Tem quem nasce com metade
e vive sem reclamar;
baixar não é ficar sem —
é ter de sobra pra dar.

Mesmo com o sinal aceso
inda tem o que fazer:
teve bicho que ganhou meses
só de alguém não se render.

Refrão final
QUEM AINDA FAZ O NINHO
ainda tem o que contar!
QUEM AINDA FAZ O NINHO
não desistiu de ficar!
Em toda cepa, em todo estágio —
anota aí: dá pra segurar!

This release contains only the music track from Base by Base Episode 451.

Song title: Lower the Signal
Original Base by Base episode: 451: Prion protein lowering is disease-modifying across stages and strains

Article metadata:
Article title: Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
Journal: Nucleic Acids Research
DOI: 10.1093/nar/gkaa616
Reference: Minikel EV, Zhao HT, Le J, O’Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-ura K, Beck M, O’Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints. Nucleic Acids Research. 2020;48(19):10615–10631. doi:10.1093/nar/gkaa616

Lyrics:
Verse 1
White coats in the midnight haze,
Quiet fear in electric days,
A tiny thread in a twisted code,
If we cut it down, can we change the road?

Pre-Chorus
Needles of language, under the skin,
Turn down the message, don’t let it win,
When the damage starts to speak in light,
We listen close, then we rewrite.

Chorus
Lower the signal, slow the fire,
Pull that shadow off the wire,
Even a little can bend the line,
Hold on—this time, time is on our side.

Verse 2
Different shapes wear the same cold grin,
Five hard rhythms, they all rush in,
But the quiet knock on the RNA door
Makes the warning fade like it did before.

Bridge
When the blood says “hurt” and the glial lights rise,
We don’t look away—we steady our eyes,
After the tipping point, we still can steer,
Some hearts come back from the edge of fear.

Final Chorus
Lower the signal, slow the fire,
Pull that shadow off the wire,
Across the stages, the proof still shines,
Hold on—this time, time is on our side.

This release contains only the music track from Base by Base Episode 450.

Song title: Ainda Tem Chão
Original Base by Base episode: 450: PrP-Lowering ASOs Extend Survival in Prion-Infected Mice

Article metadata:
Article title: Antisense oligonucleotides extend survival of prion-infected mice
Journal: JCI Insight
DOI: 10.1172/jci.insight.131175
Reference: Raymond GJ, Zhao HT, Race B, et al. Antisense oligonucleotides extend survival of prion-infected mice. JCI Insight. 2019;4(16):e131175. doi:10.1172/jci.insight.131175.

Lyrics:
Verso 1
Quando o estrago já começou o mundo diz que acabou
Fecha a porta, apaga a luz, olha o que restou
Mas tem gente que chega atrasada e mesmo assim entra
Senta na cadeira, encara de perto e não se arrepende

Porque se o corpo ainda fabrica, ainda tem o que parar
Ninguém volta atrás no tempo, mas dá pra segurar
Não é sonho de moleque, é conta que fecha na mão
Cada dia que se ganha é um dia que teve razão

Pré-refrão
Uma fita só, sozinha, procurando o endereço
Não é sorte — foi desenhada, sabe bem o que faz
Acha o recado no barulho e manda fazer menos
E o que ia virar estrago some antes de virar

Refrão
AINDA TEM CHÃO!
Chegou tarde e mesmo assim mudou a direção
AINDA TEM CHÃO!
Quem disse que era o fim falou cedo demais, irmão

Verso 2
No bicho pequeno o relógio já corria solto
E mesmo assim o ponteiro atrasou — tá medido, tá posto
Não é pouco o que se ganha quando o pouco vale tudo
Cada semana que sobrou é semana que alguém viveu

Mas segura essa manchete, não inventa milagre não
O que valeu no bicho ainda não valeu no irmão
O que esse trabalho fez foi destrancar uma porta
E porta destrancada é convite — não é chegada

Ponte
Mesmo com o estrago já dentro do salão
Mesmo com a noite inteira pesando no chão
Ainda dá pra baixar o volume da dor
Freia a dobra errada, segura o pior

Refrão Final
AINDA TEM CHÃO!
Chegou tarde e mesmo assim mudou a direção
AINDA TEM CHÃO!
Quem disse que era o fim falou cedo demais, irmão

AINDA TEM CHÃO!
AINDA TEM CHÃO!
Se dá pra mexer no fim, então mexe, irmão

This release contains only the music track from Base by Base Episode 449.

Song title: Corta a Fita, Salva a Luz
Original Base by Base episode: 449: Divalent siRNA for prion disease

Article metadata:
Article title: Divalent siRNA for prion disease
Journal: Nucleic Acids Research
DOI: 10.1093/nar/gkag287
Reference: Gentile JE, Corridon TL, Serack FE, et al. Divalent siRNA for prion disease. Nucleic Acids Research. 2026;54:gkag287. doi:10.1093/nar/gkag287

Lyrics:
Verso 1
Três da manhã, luz branca, e a cidade lá fora
Aqui dentro é a mesma vigília de sempre, sem hora
Tem um erro de cópia que copia e não pede licença
Entra devagar, se instala, e a casa nem sente a presença

Não é briga de rua, é briga por dentro
Sem barulho, sem aviso, só ganhando terreno
Mas quem vira noite aprende a escutar o que é fraco
E o que a gente escutou virou mapa, virou plano, virou ataque

Pré-refrão
Duas fitas, um elo, de mãos dadas na missão
Sozinha ela trava na porta, junto ela passa o portão
Sem estardalhaço, sem alarde, acha o endereço na hora
E o recado que fazia o estrago perde a força e vai embora

Refrão
CORTA A FITA — SALVA A LUZ!
(corta a fita — salva a luz!)
Não é apagar, é proteção
CORTA A FITA — SALVA A LUZ!
(corta a fita — salva a luz!)
Quem faz menos ruído segura o chão

Verso 2
Não é milagre de novela, é bancada e paciência
É repetir o mesmo teste até que vire evidência
Uma dose, e o efeito não some quando o dia clareia
Atravessa a semana, vira mês, e ainda tá firme na veia

O que era barulho agora é quase nada
Sobrou tão pouco que a régua mal marca
Não é vitória gritada em cima da hora
É assinatura de quem entra e não vai embora

Ponte
Segura a euforia — que ninguém aqui prometeu
Fase um pergunta o básico: é seguro ou não é?
Sem atalho, sem milagre embalado pra vender
É gente virando noite pra que outro possa amanhecer

E quem desenhou a chave carrega a mesma fechadura
Ergue a ponte pra geral, e também pra noite futura

Refrão Final
CORTA A FITA — SALVA A LUZ!
(corta a fita — salva a luz!)
Não é apagar, é proteção
CORTA A FITA — SALVA A LUZ!
(corta a fita — salva a luz!)
Quem faz menos ruído segura o chão

CORTA A FITA — SALVA A LUZ!
CORTA A FITA — SALVA A LUZ!
E a luz fica pra alguém

This release contains only the music track from Base by Base Episode 448.

Song title: Silence the Spark
Original Base by Base episode: 448: PrP‑lowering ASOs prolong survival in prion‑infected mice

Article metadata:
Article title: Antisense oligonucleotides extend survival of prion‑infected mice
Journal: JCI Insight
DOI: 10.1172/jci.insight.131175
Reference: Raymond GJ, Tran Zhao H, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O’Keefe R, Lubke LDL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM. Antisense oligonucleotides extend survival of prion‑infected mice. JCI Insight. 2019;4(16):e131175. https://doi.org/10.1172/jci.insight.131175.

Lyrics:
Verse 1
Late-night benches, glass and steel,
A quiet hunter you can’t feel,
One wrong fold makes shadows grow,
In fragile circuits moving slow.

Pre-Chorus
But on the screen a pattern clears,
A simple cut through tangled fears,
Turn the message down at the source,
And change the ending, change the course.

Chorus
Silence the spark, slow the storm,
Lower the signal, keep the form,
If the script won’t shout, the fire won’t start,
We buy back time, we guard the heart.
Silence the spark, let dawn arrive.

Verse 2
A measured dose, then wait and see,
Threads of warning in chemistry,
Not by luck, not by disguise—
It’s RNA where the answer lies.

Bridge
Even when the damage is written in the halls,
Even when the night feels heavy on the walls,
You can still pull the volume from the pain,
Slow the misfold, break the chain.

Final Chorus
Silence the spark, slow the storm,
Lower the signal, keep the form,
Less of the maker, less of the mark,
Misfolded mountains fade to dark.
Silence the spark—let life extend,
Hold the line, and bend the end.

This release contains only the music track from Base by Base Episode 447.

Song title: Cut the Thread, Save the Light
Original Base by Base episode: 447: Divalent siRNA for prion disease

Article metadata:
Article title: Divalent siRNA for prion disease
Journal: Nucleic Acids Research
DOI: 10.1093/nar/gkag287
Reference: Gentile JE, Corridon TL, Serack FE, Echeverria D, Kennedy ZC, et al. Divalent siRNA for prion disease. Nucleic Acids Research. 2026;54:gkag287. doi:10.1093/nar/gkag287

Lyrics:
Verse 1
In a room of quiet hazard, we watch the shadows grow,
A single misfolded whisper turns the whole mind slow.
But on bright screens and late-night benches, we draw a cleaner map,
Two strands tied like a promise, set inside a molecular trap.

Pre-Chorus
Load it in the RISC machine, let the blades find what’s wrong,
Less heavy armor on the ends, still stable, still strong.
A small “UU” at the finish—like a key in the lock,
And the message starts to falter, like footsteps losing clock.

Chorus
Cut the thread, cut the thread—leave the silence where it spread,
Turn the volume down on PrP, let the danger lose its head.
Hold it deep, hold it long—months of calm from one clean start,
If we can lower what we’re making, we can change the ending’s part.

Verse 2
In living brain landscapes, the numbers finally move,
Seventeen percent remaining—proof that proof can prove.
From early days of dosing to a late, last-minute chance,
Time stretches out in survival curves—new room for life to dance.

Bridge
Not every corner gets the same share of the tide,
And some questions stay behind a safety door, locked tight.
But the lead runs clean through testing, no red flags in the line,
So we aim for first footsteps—human time.

Final Chorus
Cut the thread, cut the thread—leave the silence where it spread,
Turn the volume down on PrP, let the danger lose its head.
Hold it deep, hold it long—let the night release its grip,
Two strands, one clear direction—watch the future start to shift.

This release contains only the music track from Base by Base Episode 446.

Song title: Signals in the Quiet Antenna
Original Base by Base episode: 446: Cilia, Synuclein, and Survival: G51D Mice Reveal a Shared Parkinson’s Pathway

Article metadata:
Article title: Selective loss of primary cilia and neurotrophic signaling in G51D α- synuclein mice highlights a common pathway to Parkinson’s disease
Journal: PNAS
DOI: 10.1073/pnas.2619797123
Reference: Lin Y‑E, Chiang C‑Y, et al., Selective loss of primary cilia and neurotrophic signaling in G51D α‑synuclein mice highlights a common pathway to Parkinson’s disease. Proc Natl Acad Sci U S A. 2026;123:e2619797123. doi:10.1073/pnas.2619797123

Lyrics:
Verse 1
In the hush of cells where the bright sparks run,
Tiny antennae fade, one by one.
Not every neighbor breaks the same,
Some keep the light, some lose the flame.

Pre-Chorus
A misfolded whisper builds into weight,
Cuts the wire before the message can translate.
When the doorway shuts, the garden goes dim,
And the songs that heal can’t reach the limb.

Chorus
Bring back the signal, let it come alive,
Turn the key where the hidden pathways drive.
If the cilia fall, we raise a new line,
Find the thread of hope in a brittle design.
Hold on—hear the factors call,
We’re not done when the antennas fall.

Verse 2
In chosen circuits, the loss feels precise,
While others stand steady at the same cold price.
A pathway meant to guide and grow
Runs low, runs quiet, down below.

Bridge
So we map the silence, frame by frame,
Dots of proof in a midnight pane.
If one route converges through shadowed air,
We’ll build a bridge of care right there.

Final Chorus
Bring back the signal, let it come alive,
Turn the key where the hidden pathways drive.
If the cilia fall, we raise a new line,
Feed the glow again—make the future align.
Hold on—hear the factors call,
We’re not done when the antennas fall.

This release contains only the music track from Base by Base Episode 445.

Song title: Dimers in the Dawn
Original Base by Base episode: 445: Why Thymine Survived the UV: Photodamage Pathways Explained

Article metadata:
Article title: UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems
Journal: PNAS
DOI: 10.1073/pnas.2615278123
Reference: Khosh Abady K, Karpourazar N, Rentzepis PM. UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems. PNAS. 2026. doi:10.1073/pnas.2615278123

Lyrics:
Verse 1
On a cold bright edge of water and stone,
UVC poured down where the first codes were grown.
Two letters stood there in the violet light,
One bruised fast, one broke deep in the night.

Pre-Chorus
Thymine flared hard, took the hit, didn’t run,
Uracil shimmered—then the damage was done.
A choice in the glare, no enzymes around,
Just physics and patience in the ice-packed ground.

Chorus
Make it bend, don’t let it break—
Turn the wound into a shape you can shake.
Cyclobutane, close the loop, hold the line,
In the blast of the sky, we learned to self-assign.
From the burn to the repair, to the message in time—
Thymine in the dawn, dimers in the dawn.

Verse 2
Absorbance falling like a fast-ticking clock,
Fluorescence rising from a photoproduct shock.
Some scars fade back, some lock in for good,
(6-4) shadows where CPDs withstood.

Bridge
Read the Raman whispers—bands in a row,
Signatures telling you what healed, what won’t let go.
A ratio like a warning after lamps go blue,
Will the pathogen recover, will the damage stay true?
In every bright screen, in every sterilized hall,
The old ultraviolet lesson echoes through it all.

Final Chorus
Make it bend, don’t let it break—
Choose the pathway you can unmake.
Channel the hit to a reversible sign,
So the code can return, so the thread can align.
From the first frozen nights to the clean-room sun—
Thymine in the dawn, dimers in the dawn.

This release contains only the music track from Base by Base Episode 444.

Song title: Curves in the Watch
Original Base by Base episode: 444: Many-eyes or Sentinels? How Cost Curvature Shapes Collective Vigilance

Article metadata:
Article title: Many-eyes and sentinels in selfish and cooperative groups
Journal: PNAS
DOI: 10.1073/pnas.2536017123
Reference: Pilgrim C, Bate AM, Sigalou A, Aellen M, Morford J, Warren E, Krupenye C, Biro D, Mann RP. Many-eyes and sentinels in selfish and cooperative groups. PNAS. 2026;123(33):e2536017123. doi:10.1073/pnas.2536017123

Lyrics:
Verse 1
In the hush of a restless edge,
Eyes trade time like borrowed light,
Every glance a tiny pledge,
Against the dark that hunts the night.

Pre-Chorus
If the price of looking rises fast,
We share it thin, we spread it wide,
But if the cost can soften past,
One brave gaze becomes our guide.

Chorus
Many eyes, low and steady—hold the line,
Or one sentinel, burning bright, a single sign,
Convex or concave, the choice is drawn in code,
In the curve of what we spend, in the weight of what we owe.

Verse 2
Selfish hearts or hands aligned,
Still the math keeps time the same,
When the threat shifts, we redraw the line,
And switching feels like changing flame.

Bridge
Not every body pays alike—there’s an edge that pulls and bends,
Energy runs in circles, so the lookout role can spend,
Take your turn, then trade it back, let the tired ones descend,
A rotating crown of caution where the night and daylight blend.

Final Chorus
Many eyes, low and steady—hold the line,
Or one sentinel, burning bright, a single sign,
It’s not just will, it’s how the cost becomes the load,
In the curve of what we spend, we find the way we hold.

This release contains only the music track from Base by Base Episode 444.

Song title: Curves in the Watch
Original Base by Base episode: 444: Many-eyes or Sentinels? How Cost Curvature Shapes Collective Vigilance

Article metadata:
Article title: Many-eyes and sentinels in selfish and cooperative groups
Journal: PNAS
DOI: 10.1073/pnas.2536017123
Reference: Pilgrim C, Bate AM, Sigalou A, Aellen M, Morford J, Warren E, Krupenye C, Biro D, Mann RP. Many-eyes and sentinels in selfish and cooperative groups. PNAS. 2026;123(33):e2536017123. doi:10.1073/pnas.2536017123

Lyrics:
Verse 1
In the hush of a restless edge,
Eyes trade time like borrowed light,
Every glance a tiny pledge,
Against the dark that hunts the night.

Pre-Chorus
If the price of looking rises fast,
We share it thin, we spread it wide,
But if the cost can soften past,
One brave gaze becomes our guide.

Chorus
Many eyes, low and steady—hold the line,
Or one sentinel, burning bright, a single sign,
Convex or concave, the choice is drawn in code,
In the curve of what we spend, in the weight of what we owe.

Verse 2
Selfish hearts or hands aligned,
Still the math keeps time the same,
When the threat shifts, we redraw the line,
And switching feels like changing flame.

Bridge
Not every body pays alike—there’s an edge that pulls and bends,
Energy runs in circles, so the lookout role can spend,
Take your turn, then trade it back, let the tired ones descend,
A rotating crown of caution where the night and daylight blend.

Final Chorus
Many eyes, low and steady—hold the line,
Or one sentinel, burning bright, a single sign,
It’s not just will, it’s how the cost becomes the load,
In the curve of what we spend, we find the way we hold.