Base by Base - Music

This release contains only the music track from Base by Base Episode 99.

Song title: Through the Nuclear Door
Original Base by Base episode: 99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

Article metadata:
Article title: NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis
Journal: Nature Communications
DOI: 10.1038/s41467-025-61463-0
Reference: Dicke A-K, Ahmedani A, Ma L, Herrmann L, van der Heijden GW, Koser SA, Krallmann C, Kalyon O, Xavier MJ, Veltman JA, Kliesch S, Neuhaus N, Kotaja N, Tüttelmann F & Stallmeyer B. NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis. Nature Communications. 2025;16:6254. doi:10.1038/s41467-025-61463-0

Lyrics:
Verse 1
Late-night lab lights, a quiet hum
Messages waiting where the shadows run
Letters of life in a folded code
But they don’t become real till they hit the road

Pre-Chorus
There’s a gate in the middle of the cell
A lock that knows the stories well
If the courier disappears from view
The whole bright future can’t break through

Chorus
Send it out, send it on, through the nuclear door
When the signal’s stuck, you can’t make any more
One missing link and the anthem turns to noise
But when it’s in place, it can build new boys
Send it out, send it on—let the blueprint roar

Verse 2
A testis-tuned team on the membrane line
Handing off cargo in perfect time
Partners align like a two-part key
And the pore lights up like a runway beam

Bridge
If NXT2 goes silent, the chain comes undone
No protein rising, no race to be won
Cells stall out where the promise starts
Empty halls in the tender parts
So we name the gap, so we trace the cause

Final Chorus
Send it out, send it on, through the nuclear door
Now we see what the missing piece was for
From a break in the path to a clear diagnosis
From a closed-off chance to a new prognosis
Send it out, send it on—let the blueprint soar

This release contains only the music track from Base by Base Episode 98.

Song title: Accordion of Cells
Original Base by Base episode: 98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

Article metadata:
Article title: Cell Marker Accordion: interpretable single-cell and spatial omics annotation in healthand disease
Journal: Nature Communications
DOI: 10.1038/s41467-025-60900-4
Reference: Busarello E., Biancon G., Cimignolo I., et al. Cell Marker Accordion: interpretable single-cell and spatial omics annotation in healthand disease. Nature Communications (2025). DOI: 10.1038/s41467-025-60900-4

Lyrics:
Verse 1
Late-night screens in a humming lab
Millions of whispers in a single tab
Clusters blooming where the colors run
But who is who when the map’s begun?

Pre-Chorus
So we gather every name we can find
Test what’s true, leave the noise behind
Weight the signal, let the evidence speak
Turn the chaos into something we can read

Chorus
Open the Cell Marker Accordion—hear it ring
Fold by fold, let the right tags sing
From the blood to the brain, in the tissue glow
Faster, clearer—now the hidden cells show

Verse 2
Some markers shout, some barely breathe
Some agree, some mislead
So we score each gene by what it proves
Specific and steady—no guesswork grooves

Bridge
In the shadows where the sickness grows
There’s a critical crowd nobody knows
Pathways waking, cycles breaking, quiet turning loud
And the answer rises like a chorus from the crowd

Final Chorus
Open the Cell Marker Accordion—hear it ring
Fold by fold, let the right tags sing
Find the rare ones, find the turning point
Annotate the truth till the picture clicks into joint

This release contains only the music track from Base by Base Episode 95.

Song title: Borrowed Fire
Original Base by Base episode: 95: Mitochondria transfer: biotech strategies and clinical hurdles

Article metadata:
Article title: Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation
Journal: Nature Communications
DOI: 10.1038/s41467-025-61239-6
Reference: Kubat GB, Picone P, Tuncay E, et al. Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation. Nature Communications. 2025;16:5709. doi:10.1038/s41467-025-61239-6

Lyrics:
Verse 1
Two hours on the bench, then the spark can fade
Cold spin, clean split, keep the power from decay
In a glass-lit midnight, we’re chasing what was lost
A tiny engine humming at a human cost

Pre-Chorus
Will it dock or disappear in acid rain?
Will it wire in, or break apart in vain?
So we dress it up in molecules that guide
Give it armor, give it a ride

Chorus
Send the borrowed fire, let it light the dark
Get it past the gates, let it find the heart
If it fuses, we rise—if it falls, we learn
Hold that rhythm steady till the circuits return

Verse 2
Pep-1 on the surface, TAT in the chain
Dextran on the edges, whispering a name
Vesicles like lifeboats through the calcium storm
Lipids like a hallway, keeping function warm

Bridge
But the body asks questions, alarms in the blood
Targets hard to reach in the stubborn flood
Scale it clean, make it safe, make it real
From the lab to the living—prove what we can heal

Final Chorus
Send the borrowed fire, let it light the dark
Coat it, cage it, steer it—straight to the spark
Through the ward-room silence, through the sleepless nights
We don’t just move power—we return the lights

This release contains only the music track from Base by Base Episode 94.

Song title: Same Body, Different Codes
Original Base by Base episode: 94: Intraindividual epigenetic heterogeneity in advanced prostate cancer

Article metadata:
Article title: Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer
Journal: Nature Communications
DOI: 10.1038/s41467-025-60654-z
Reference: Mizuno K., Ku S-Y., Venkadakrishnan VB., et al. Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer. Nature Communications (2025). DOI: https://doi.org/10.1038/s41467-025-60654-z

Lyrics:
Verse 1
One patient, many shadows on the scan
Same name on the chart, different plans
Quiet switches in the methylation light
Lineage stories changing overnight

Pre-Chorus
Marks on the genome, drifting like smoke
A surface flag can vanish as a joke
If we don’t look close, we miss the sign
Right target, wrong time

Chorus
Same body, different codes
Different keys in different roads
Read the silence, read the glow
Find the door before it closes
Same body, different codes
But we learn where the signal goes
Map the marks, then choose the shot
Hit what’s there, not what we thought

Verse 2
Across the spread, some patterns still align
But one site whispers, “I’m not your kind”
AR goes dim, ASCL1 takes the stage
New masks turning with the page

Bridge
Double-negative, split in two
One with BMP4 breaking through
One immune-lit, sharp and wide
We trace the links we can’t deny
And when the pathway starts to shout
We dial it down and test it out

Final Chorus
Same body, different codes
Different storms in different nodes
Read the silence, read the glow
Bring the therapy where it goes
Same body, different codes
Now the map is what we hold
Methyl marks and open chromatin
Say when to strike—so we can win

This release contains only the music track from Base by Base Episode 93.

Song title: Milk-Route Midnight
Original Base by Base episode: 93: Bovine H5N1 Shows Neurovirulence in Mice

Article metadata:
Article title: Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease
Journal: Nature Communications
DOI: 10.1038/s41467-025-60407-y
Reference: Tipih T., Mariaappan V., Yinda K.C., Meade-White K., Lewis M., Okumura A., McCarthy N., Altynova E., Leventhal S.S., Bushmaker T., Clancy C.S., de Wit E., Munster V.J., Feldmann H. & Rosenke K. Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease. Nature Communications (2025) 16:5738. DOI: 10.1038/s41467-025-60407-y

Lyrics:
Verse 1
Under cold fluorescents, the warning starts to sing
A feathered shadow learning how to sting
In quiet cages, the numbers climb too fast
Breath turns shallow, and the calm can’t last

Pre-Chorus
From lung to bloodline, like a runaway spark
A thin red river cutting through the dark
Not every answer fits in what we know
But you can feel it moving as it goes

Chorus
It’s in the lungs, it’s in the brain—too close, too near
A bright-screen siren in the static of our fear
Trace that thread, don’t look away, don’t freeze
Name the path, break the chain, hold the line with me

Verse 2
A swallow of the wrong thing—then the world tilts strange
Same virus, new doorway, same ruthless change
One strain hits harder, like it found a key
Turns air to thunder, steals your gravity

Bridge
Cytokine rain in the midnight sky
Signals flaring where the defenses rise
We don’t claim the map is finished or complete
But we can test the shields before the next stampede

Final Chorus
It’s in the lungs, it’s in the brain—too close, too near
A bright-screen siren in the static of our fear
Run the model, run the trials, make the answers breathe
Catch the spark, close the gate—hold the line with me

This release contains only the music track from Base by Base Episode 92.

Song title: Turn Down the FHR-5
Original Base by Base episode: 92: Loss of CFHR5 Function Lowers AMD Risk

Article metadata:
Article title: Loss of CFHR5 function reduces the risk for age-related macular degeneration
Journal: Nature Communications
DOI: 10.1038/s41467-025-61193-3
Reference: https://doi.org/10.1038/s41467-025-61193-3

Lyrics:
Verse 1
Late-night lab glow, numbers on a screen
A silent storm where the light should stay clean
In the blood, a switch we never saw before
A missing piece at the retinal door

Pre-Chorus
If the shield is overbuilt, it turns on you
So we trace the break where the signal goes through
Less of one factor, more control in sight
A quieter fire, a sharper night

Chorus
Turn down the FHR-5, let the vision breathe
Let the line stay bright where the years would grieve
Complement rising, but it won’t collide
When the wrong key’s gone, the system aligns
Turn down the FHR-5—hold the light inside

Verse 2
Haplotypes like footsteps, mapping what they mean
Frameshift cut clean, like a seam unseen
FHR-2 and FHR-4 fade low in the mix
And the pathways wake up—still they don’t break what they fix

Bridge
Photoreceptors holding shape, layer by layer
A softer edge to the wear-and-tear
No hidden cost in the wider scan
Just one small change with a steady hand
So maybe the cure is a careful decrease
A gentle downshift, a long-held peace

Final Chorus
Turn down the FHR-5, let the vision breathe
Let the line stay bright where the years would grieve
From blood to the back of the eye, we find
A safer balance by redesign
Turn down the FHR-5—keep the future in sight

This release contains only the music track from Base by Base Episode 91.

Song title: Sugar Codes on the Edge of Fire
Original Base by Base episode: 91: Plasma N‑Glycome, Liver Disease & Anti‑inflammatory Proteins

Article metadata:
Article title: A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins
Journal: Nature Communications
DOI: 10.1038/s41467-025-60431-y
Reference: Sharapov S, Timoshchuk A, Zaytseva O, et al. A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins. Nature Communications. 2025;16:5525. doi:10.1038/s41467-025-60431-y

Lyrics:
Verse 1
Midnight in the lab, bright screen, steady glow
Ten thousand lives in numbers, letting patterns show
Little sugar branches dancing on the proteins we know
A secret map in plasma, where the quiet currents flow

Pre-Chorus
Every peak a clue, every shift a sign
Genes pull the strings in networks, crossing every line
From liver-made to immune-made, the signals realign

Chorus
Read the sugar codes, let them light the way
From inflammation’s echo to the scars we cannot name
If the liver’s under pressure, we can hear it in the frame
New markers, new targets—turn the dark into a flame
Read the sugar codes, let them light the way

Verse 2
Forty strong loci calling, like a pulse beneath the skin
Some old doors swing open, and some new roads begin
Tissue-specific whispers—where the healing can get in
A glycan score predicting where the risks are settling in

Bridge
High-mannose rising—lipids start to sway
Another strand points to breath that breaks and frays
Not destiny, just leverage—now we know what to assay
So we can shift the pathway, not just watch it day by day

Final Chorus
Read the sugar codes, let them light the way
From metabolic trouble to the fire of inflammation’s name
Candidate genes, clear signals—giving science something to claim
New markers, new targets—turn the dark into a flame
Read the sugar codes, let them light the way

This release contains only the music track from Base by Base Episode 30.

Song title: The Quiet Switch
Original Base by Base episode: 30: Bi‑allelic POPDC2 variants and a recessive cardiac conduction syndrome

Article metadata:
Article title: Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2025.04.016
Reference: Nicastro M, Vermeer AMC, Postema PG, et al. Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy. The American Journal of Human Genetics. 2025;112:1–18. doi:10.1016/j.ajhg.2025.04.016

Lyrics:
Verse 1
In the quiet muscle where the lightning lives,
A tiny signal slips, a fragile rhythm gives.
Two hidden letters in the code align,
And the hallway heartbeat loses track of time.

Pre-Chorus
We trace it through the long-night glow of screens,
Through looping lines and in-between.
A missing grip on what should hold so tight,
And every pause is louder than the night.

Chorus
Turn the current back on, let it run, let it run,
When the pulse goes low, we follow where it’s from.
If the switch won’t bind, the drum can’t find its way,
But we named the break—now we can light the relay.

Verse 2
Models in the shadows show the pocket’s flaw,
cAMP can’t land where it used to draw.
And channels meant to breathe, to keep the tempo free,
Go still—no lift in the TREK-1 sea.

Bridge
In the node where timing learns to start,
A few cells hold the map of every heart.
Not everyone who carries it will fall,
But for some, two echoes silence the call.

Final Chorus
Turn the current back on, let it run, let it run,
When the pulse goes low, we follow where it’s from.
From the membrane fade to the wire that frays,
We named the break—now we can change the days.

This release contains only the music track from Base by Base Episode 29.

Song title: Keys in Our Hands
Original Base by Base episode: 29: Rethinking Agency: Predictors of Genetic Testing Intention among Latinos

Article metadata:
Article title: Rethinking Agency for Genetic Testing Intention among Latinos: Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing
Journal: Genetics in Medicine
DOI: https://doi.org/10.1016/j.gim.2025.101455
Reference: Chavez-Yenter D, Kaphingst KA. Rethinking Agency for Genetic Testing Intention among Latinos: Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing. Genetics in Medicine (2025). doi: https://doi.org/10.1016/j.gim.2025.101455

Lyrics:
Verse 1
Late night forms on a bright blue screen,
Questions land where fears have been.
Two roads open, same new light,
Carrier lines and cancer signs.

Pre-Chorus
It’s not just knowing names and charts,
It’s finding doors and steady hearts.
A map, a ride, a hand to hold—
That’s how the future starts to unfold.

Chorus
Give me agency, give me a way,
A clear next step when I’m afraid.
When the choice feels heavy, I can stand—
With keys in my hands, keys in my hands.

Verse 2
Voices circle close like family,
“Do it for tomorrow,” quietly.
But attitudes can twist like wire,
Even facts don’t always lift you higher.

Bridge
Build the pathways, make it real,
Not just information—help me feel
I can reach the test, I can be seen,
Turn intention into something clean.

Final Chorus
Give me agency, give me a way,
A clear next step when I’m afraid.
We don’t just hope—we make a plan,
With keys in our hands, keys in our hands.

This release contains only the music track from Base by Base Episode 27.

Song title: Sealed at the 3' End
Original Base by Base episode: 27: ENVLPE+: Shuttling VLPs that load functional CRISPR RNPs

Article metadata:
Article title: Engineered nucleocytosolic vehicles for loading of programmable editors
Journal: Cell
DOI: 10.1016/j.cell.2025.03.015
Reference: Geilenkeuser J., Armbrust N., Steinmaßl E., et al. Engineered nucleocytosolic vehicles for loading of programmable editors. Cell. 2025;188:2637–2655. https://doi.org/10.1016/j.cell.2025.03.015

Lyrics:
Verse 1
We stayed up late with bright screens humming low,
Built little carriers that know where to go,
From nucleus out to the cytosol tide,
Packing the tools with the edits inside.

Pre-Chorus
Not just the code, but the whole machine,
RNPs ready, sharp and clean,
And when the RNA starts to fray—
We lock it up, we don’t let it fade.

Chorus
Send it, ship it, let it ride the wave,
Keep that guide alive, keep it brave,
Seal at the 3' end, hold on tight,
Turn the wrong to right in a pulse of light.

Verse 2
Aptamer latches—click—pull it near,
Load it heavy, particle-to-particle clear,
More per capsule, more that lands,
Less guesswork in our steady hands.

Bridge
And down the quiet halls where signals dim,
A spark returns at the edge of vision,
Protein back where it used to be,
Not perfect—still—a door in the key.

Final Chorus
Send it, ship it, let it ride the wave,
Keep that guide alive, keep it brave,
Seal at the 3' end, hold on tight,
From dark to dawn in a pulse of light,
Yeah, seal at the 3' end—watch it ignite.